
Overview
Background
Professor Mark Schembri is a prominent microbiologist with experience in combating the global health crisis presented by multi-drug resistant pathogens. Professor Schembri’s expertise on the virulence of bacterial pathogens and his innovative analysis of biofilm formation aims to improve the outcomes of the >400 million individuals that suffer from urinary tract infections each year across the globe.
Through the application of genetic, genomic and functional studies on uropathogenic E. coli, Professor Schembri has identified targets to reduce the virulence of this pathogen, and will pursue the development of life-saving therapeutic and preventative advances with the assistance of NHMRC, MRFF and ARC grants. Professor Schembri has tracked the rapid emergence and global spread of a virulent, drug-resistant E. coli clone and used genome sequencing to understand its evolution and virulence.
Links: Professor Schembri collaborates with national and international research leaders, including in Denmark, where he was a lecturer. Professor Schembri has strong links with other international experts in his field, including at the Pasteur Institute and the Wellcome Trust Sanger Institute in Cambridge. His research collaborations also span lead groups at UQ and other top Australian institutes, including Griffith and La Trobe Universities.
Membership, Funding and patents: Since 2014, Professor Schembri has been awarded over $15 million in funding from competitive national research funding bodies. He holds provisional patents for the development of novel therapeutic agents and vaccine antigens. He is a Fellow of the American Academy of Microbiology, and is regularly invited to speak at international conferences in his field.
Awards and Communication: Professor Schembri was the recipient of the Frank Fenner Award (2010) and the ASM BacPath Oration Award (2019) for his outstanding original research contribution to the study of Infectious Disease. He was an Australian Research Council Future Fellow (2011-2015) a National Health and Medical Research Council Senior Research Fellow (2016-2020). Professor Schembri is the author of >240 peer-reviewed research manuscripts. He is President of the Australian Society for Microbiology (2022-2026).
Availability
- Professor Mark Schembri is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Monash University
Research impacts
Professor Schembri’s outstanding original work in the field of infectious disease and multi-drug resistant pathogens has led to several key advances in the fight to reduce the prevalence and improve outcomes of urinary tract infections.
Key research outputs: The genomic epidemiology of the most widespread antibiotic resistant uropathogenic E. coli clone allowed its origin and dissemination to be mapped on a global scale. Recent work in Professor Schembri’s group has defined the virulence of this pathogen using advanced genetic, transcriptomic and proteomic methods in conjunction with mouse models of infection. He has also led the use of new treatments to prevent infection by this antibiotic resistant pathogen.
Key capabilities: Professor Schembri has deep expertise in microbiology, with particular capability in the study of antibiotic resistant Gram-negative bacterial pathogens and high-throughput modelling of drug-resistant biofilms, as well as the application of forefront technologies to examine virulence, genomic epidemiology, host-pathogen interactions and novel strategies for the treatment/prevention of infectious diseases.
Works
Search Professor Mark Schembri’s works on UQ eSpace
2015
Journal Article
Do You Kiss Your Mother with That Mouth? An Authentic Large-Scale Undergraduate Research Experience in Mapping the Human Oral Microbiome
Wang, Jack T.H., Daly, Joshua N., Willner, Dana L., Patil, Jayee, Hall, Roy A., Schembri, Mark A., Tyson, Gene W. and Hugenholtz, Philip (2015). Do You Kiss Your Mother with That Mouth? An Authentic Large-Scale Undergraduate Research Experience in Mapping the Human Oral Microbiome. Journal of Microbiology and Biology Education, 16 (1), 50-60. doi: 10.1128/jmbe.v16i1.816
2015
Journal Article
Blocking the 'MIDAS' touch of Enterococcus faecalis.
Schembri, Mark A., Lo, Alvin W. and Ulett, Glen C. (2015). Blocking the 'MIDAS' touch of Enterococcus faecalis.. Annals of Translational Medicine, 3 (Suppl.1) S3, S3. doi: 10.3978/j.issn.2305-5839.2015.03.32
2015
Journal Article
Molecular analysis of asymptomatic bacteriuria Escherichia coli strain VR50 reveals adaptation to the urinary tract by gene acquisition
Beatson, Scott A., Ben Zakour, Nouri L., Totsika, Makrina, Forde, Brian M., Watts, Rebecca E., Mabbett, Amanda N., Szubert, Jan M., Sarkar, Sohinee, Phan, Minh-Duy, Peters, Kate M., Petty, Nicola K., Alikhan, Nabil-Fareed, Sullivan, Mitchell J., Gawthorne, Jayde A., Stanton-Cook, Mitchell, Nguyen Thi Khanh Nhu, Chong, Teik Min, Yin, Wai-Fong, Chan, Kok-Gan, Hancock, Viktoria, Ussery, David W., Ulett, Glen C. and Schembri, Mark A. (2015). Molecular analysis of asymptomatic bacteriuria Escherichia coli strain VR50 reveals adaptation to the urinary tract by gene acquisition. Infection and Immunity, 83 (5), 1749-1764. doi: 10.1128/IAI.02810-14
2015
Journal Article
Molecular Characterization of a Multidrug Resistance IncF Plasmid from the Globally Disseminated Escherichia coli ST131 Clone.
Phan, Minh Duy, Forde, Brian M., Peters, Kate M., Sarkar, Sohinee, Hancock, Steven, Stanton-Cook, Mitchell, Zakour, Nouri L. Ben, Upton, Mathew, Beatson, Scott A. and Schembri, Mark A. (2015). Molecular Characterization of a Multidrug Resistance IncF Plasmid from the Globally Disseminated Escherichia coli ST131 Clone.. PLoS One, 10 (4) e0122369, e0122369-e0122369. doi: 10.1371/journal.pone.0122369
2015
Journal Article
Third-generation cephalosporin resistance conferred by a chromosomally encoded blaCMY-23 gene in the Escherichia coli ST131 reference strain EC958
Phan, Minh-Duy, Peters, Kate M., Sarkar, Sohinee, Forde, Brian M., Lo, Alvin W., Stanton-Cook, Mitchell, Roberts, Leah W., Upton, Mathew, Beatson, Scott A. and Schembri, Mark A. (2015). Third-generation cephalosporin resistance conferred by a chromosomally encoded blaCMY-23 gene in the Escherichia coli ST131 reference strain EC958. Journal of Antimicrobial Chemotherapy, 70 (7) dkv066, 1969-1972. doi: 10.1093/jac/dkv066
2015
Journal Article
Comparative analysis of the uropathogenic Escherichia coli surface proteome by tandem mass-spectrometry of artificially induced outer membrane vesicles
Wurpel, Daniel J., Moriel, Danilo G., Totsika, Makrina, Easton, Donna M. and Schembri, Mark A. (2015). Comparative analysis of the uropathogenic Escherichia coli surface proteome by tandem mass-spectrometry of artificially induced outer membrane vesicles. Journal of Proteomics, 115, 93-106. doi: 10.1016/j.jprot.2014.12.005
2015
Journal Article
The co-transcriptome of uropathogenic Escherichia coli-infected mouse macrophages reveals new insights into host–pathogen interactions
Mavromatis, Charalampos (Harris), Bokil, Nilesh J., Totsika, Makrina, Kakkanat, Asha, Schaale, Kolja, Cannistraci, Carlo V., Ryu, Taewoo, Beatson, Scott A., Ulett, Glen C., Schembri, Mark A., Sweet, Matthew J. and Ravasi, Timothy (2015). The co-transcriptome of uropathogenic Escherichia coli-infected mouse macrophages reveals new insights into host–pathogen interactions. Cellular Microbiology, 17 (5), 730-746. doi: 10.1111/cmi.12397
2015
Journal Article
Urinary tract infection of mice to model human disease: Practicalities, implications and limitations
Carey, Alison J., Tan, Chee K., Ipe, Deepak S., Sullivan, Matthew J., Cripps, Allan W., Schembri, Mark A. and Ulett, Glen C. (2015). Urinary tract infection of mice to model human disease: Practicalities, implications and limitations. Critical Reviews in Microbiology, 42 (5), 780-799. doi: 10.3109/1040841X.2015.1028885
2015
Journal Article
Hospital-Wide Eradication of a Nosocomial Legionella pneumophila Serogroup 1 Outbreak
Bartley, Paul B., Ben Zakour, Nouri L., Stanton-Cook, Mitchell, Muguli, Raghuram, Prado, Luis, Garnys, Vyt, Taylor, Katherine, Barnett, Timothy C., Pinna, Glen, Robson, Jennifer, Paterson, David L., Walker, Mark J., Schembri, Mark A. and Beatson, Scott A. (2015). Hospital-Wide Eradication of a Nosocomial Legionella pneumophila Serogroup 1 Outbreak. Clinical Infectious Diseases, 62 (3), 273-279. doi: 10.1093/cid/civ870
2014
Journal Article
The intimin-like protein FdeC is regulated by H-NS and temperature in Enterohaemorrhagic Escherichia coli
Easton, Donna M., Allsopp, Luke P., Phan, Minh-Duy, Gomes Moriel, Danilo, Goh, Guan Kai, Beatson, Scott A., Mahony, Timothy J., Cobbold, Rowland N. and Schembri, Mark A. (2014). The intimin-like protein FdeC is regulated by H-NS and temperature in Enterohaemorrhagic Escherichia coli. Applied and Environmental Microbiology, 80 (23), 7337-7347. doi: 10.1128/AEM.02114-14
2014
Journal Article
The complete genome sequence of Escherichia coli EC958: a high quality reference sequence for the globally disseminated multidrug resistant E. coli O25b:H4-ST131 clone
Forde, Brian M., Ben Zakour, Nouri L., Stanton-Cook, Mitchell, Phan, Minh-Duy, Totsika, Makrina, Peters, Kate M., Chan, Kok Gan, Schembri, Mark A., Upton, Mathew and Beatson, Scott A. (2014). The complete genome sequence of Escherichia coli EC958: a high quality reference sequence for the globally disseminated multidrug resistant E. coli O25b:H4-ST131 clone. PLoS One, 9 (8) e104400, e104400.1-e104400.13. doi: 10.1371/journal.pone.0104400
2014
Conference Publication
Inoculation of cattle with novel Escherichia coli antigens reduces enteric colonisation by enterohaemorrhagic E. coli O26
Vance, Megan, Mahony, Timothy, Easton, Donna, Alikhan, Nabil, Beatson, Scott, Schembri, Mark and Cobbold, Rowland (2014). Inoculation of cattle with novel Escherichia coli antigens reduces enteric colonisation by enterohaemorrhagic E. coli O26. Australian Society for Microbiology Annual Scientific Meeting, Melbourne, VIC, Australia, 5 - 9 July 2014.
2014
Journal Article
Evaluation of a multiplex PCR to identify and serotype Actinobacillus pleuropneumoniae serovars 1, 5, 7, 12 and 15
Turni, C., Singh, R., Schembri, M. A. and Blackall, P. J. (2014). Evaluation of a multiplex PCR to identify and serotype Actinobacillus pleuropneumoniae serovars 1, 5, 7, 12 and 15. Letters in Applied Microbiology, 59 (4), 362-369. doi: 10.1111/lam.12287
2014
Conference Publication
Embedding Undergraduate Research throughout Microbiology Majors
Wang, Jack T.H., Daly, Joshua N., Willner, Dana L., Patil, Jayee, Hall, Roy, Tyson, Gene W., Hugenholtz, Philip and Schembri, Mark A. (2014). Embedding Undergraduate Research throughout Microbiology Majors. ASM Conference for Undergraduate Educators, Danvers, MA United States, 15-18 May 2014.
2014
Journal Article
Crystal Structure of the Dithiol Oxidase DsbA Enzyme from Proteus Mirabilis Bound Non-covalently to an Active Site Peptide Ligand.
Kurth, Fabian, Duprez, Wilko, Premkumar, Lakshmanane, Schembri, Mark A., Fairlie, David P. and Martin, Jennifer L. (2014). Crystal Structure of the Dithiol Oxidase DsbA Enzyme from Proteus Mirabilis Bound Non-covalently to an Active Site Peptide Ligand.. Journal of Biological Chemistry, 289 (28), 19810-19822. doi: 10.1074/jbc.M114.552380
2014
Journal Article
Global dissemination of a multidrug resistant Escherichia coli clone
Petty, Nicola K., Ben Zakour, Nouri L., Stanton-Cook, Mitchell, Skippington, Elizabeth, Totsika, Makrina, Forde, Brian M., Phan, Minh-Duy, Gomes Moriel, Danilo, Peters, Kate M., Davies, Mark, Rogers, Benjamin A., Dougan, Gordon, Rodriguez-Baño, Jesús, Pascual, Alvaro, Pitout, Johann D., Upton, Mathew, Paterson, David L., Walsh, Timothy R., Schembri, Mark A. and Beatson, Scott A. (2014). Global dissemination of a multidrug resistant Escherichia coli clone. Proceedings of the National Academy of Sciences, 111 (15), 5694-5699. doi: 10.1073/pnas.1322678111
2014
Journal Article
Role of capsule and O antigen in the virulence of uropathogenic Escherichia coli
Sarkar, Sohinee, Ulett, Glen C., Totsika, Makrina, Phan, Minh-Duy and Schembri, Mark A. (2014). Role of capsule and O antigen in the virulence of uropathogenic Escherichia coli. PLoS One, 9 (4) e94786, e94786. doi: 10.1371/journal.pone.0094786
2014
Journal Article
F9 fimbriae of uropathogenic Escherichia coli are expressed at low temperature and recognise Galβ1-3GlcNAc-containing glycans
Wurpel, Daniël J., Totsika, Makrina, Allsopp, Luke P., Hartley-Tassell, Lauren E., Day, Christopher J., Peters, Kate M., Sarkar, Sohinee, Ulett, Glen C., Yang, Ji, Tiralongo, Joe, Strugnell, Richard A., Jennings, Michael P. and Schembri, Mark A. (2014). F9 fimbriae of uropathogenic Escherichia coli are expressed at low temperature and recognise Galβ1-3GlcNAc-containing glycans. PLoS One, 9 (3) e93177, e93177. doi: 10.1371/journal.pone.0093177
2014
Journal Article
Single clinical isolates from acute uncomplicated urinary tract infections are representative of dominant In Situ populations
Willner, Dana, Low, Serene, Steen, Jason A., George, Narelle, Nimmo, Graeme R., Schembri, Mark A. and Hugenholtz, Philip (2014). Single clinical isolates from acute uncomplicated urinary tract infections are representative of dominant In Situ populations. mBio, 5 (2) e01064-13, e01064-13.1-e01064-13.10. doi: 10.1128/mBio.01064-13
2014
Journal Article
CD4+and CD8+ regulatory T cells in chronic rhinosinusitis mucosa
Pant, Harshita, Hughes, Amy, Schembri, Mark, Miljkovic, Dijana and Krumbiegel, Doreen (2014). CD4+and CD8+ regulatory T cells in chronic rhinosinusitis mucosa. American Journal of Rhinology and Allergy, 28 (2), e83-e89. doi: 10.2500/ajra.2013.28.4014
Funding
Current funding
Past funding
Supervision
Availability
- Professor Mark Schembri is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Understanding virulence factors and their regulation in uropathogenic Escherichia coli (UPEC)
Principal Advisor
Other advisors: Dr Nhu Nguyen
-
Doctor Philosophy
How bacteria form antibiotic resistant biofilms
Principal Advisor
Other advisors: Dr Nhu Nguyen, Dr Duy Phan
-
Doctor Philosophy
Diversity, regulation and function of the uropathogenic Escherichia coli capsule
Principal Advisor
Other advisors: Professor Matt Sweet, Dr Duy Phan
-
Doctor Philosophy
Application of Transposon Directed Insertion Site Sequencing to Enhance Understanding of Essential Genes in Escherichia coli
Associate Advisor
Other advisors: Professor Ian Henderson
-
Doctor Philosophy
Genomic and molecular characterisation of antibiotic resistance mechanisms
Associate Advisor
Other advisors: Dr Brian Forde
-
Doctor Philosophy
Microbial effects on host mitochondrial DNA
Associate Advisor
Other advisors: Associate Professor Steven Zuryn
-
Doctor Philosophy
Application of Transposon Directed Insertion Site Sequencing to Enhance Understanding of Essential Genes in Escherichia coli
Associate Advisor
Other advisors: Professor Ian Henderson
-
Doctor Philosophy
Identifying new targets for treatment of antimicrobial resistant infections
Associate Advisor
Other advisors: Professor Ian Henderson
-
Doctor Philosophy
Boosting innate immune defence to combat antibiotic-resistant bacterial infections
Associate Advisor
Other advisors: Dr Divya Ramnath, Professor Matt Sweet
Completed supervision
-
2024
Doctor Philosophy
Understanding virulence factors and their regulation in uropathogenic Escherichia coli (UPEC)
Principal Advisor
Other advisors: Dr Nhu Nguyen
-
2024
Doctor Philosophy
Understanding antibiotic resistance and virulence in uropathogenic Escherichia coli
Principal Advisor
Other advisors: Dr Duy Phan
-
2023
Doctor Philosophy
Understanding the regulation of biofilm matrix components in uropathogenic Escherichia coli virulence
Principal Advisor
Other advisors: Dr Nhu Nguyen
-
2023
Doctor Philosophy
Virulence and Resistance Plasmids of Extra-intestinal Pathogenic Escherichia coli
Principal Advisor
Other advisors: Dr Duy Phan
-
2022
Doctor Philosophy
Characterisation of Escherichia coli fimbrial and autotransporter adhesins
Principal Advisor
Other advisors: Dr Duy Phan
-
2019
Doctor Philosophy
Molecular characterisation of A/C plasmids
Principal Advisor
Other advisors: Dr Duy Phan
-
2018
Doctor Philosophy
Molecular and genomic analysis of multidrug resistant Uropathogenic Escherichia coli
Principal Advisor
Other advisors: Associate Professor Scott Beatson
-
2017
Doctor Philosophy
Characterisation of flagella and resistance to oxidative stress in Escherichia coli ST131 virulence
Principal Advisor
-
2017
Doctor Philosophy
Characterisation of Factors Involved in Escherichia coli Virulence: Type Ve Inverse Autotransporter Proteins and the K1 Capsule
Principal Advisor
-
2016
Doctor Philosophy
Uropathogenic Escherichia coli: Towards a Better Understanding through the Characterisation of a Vaccine Antigen and Virulence Factor
Principal Advisor
-
2016
Master Philosophy
Autotransporter Proteins of Uropathogenic Escherichia coli: Regulation, Characterisation and the Role of Periplasmic Proteins in their Expression
Principal Advisor
-
2014
Doctor Philosophy
Evolutionary Phylogeny and Molecular Characterisation of Chaperone-Usher Fimbriae from Uropathogenic Escherichia coli
Principal Advisor
-
2014
Doctor Philosophy
Investigating the Virulence Potential of the Multidrug Resistant Uropathogenic Escherichia coli ST131 clone
Principal Advisor
Other advisors: Associate Professor Scott Beatson
-
2012
Doctor Philosophy
Molecular analysis of Acinetobacter baumannii isolates from an intensive care unit
Principal Advisor
Other advisors: Associate Professor Scott Beatson
-
2011
Doctor Philosophy
Identification and Characterisation of New Adhesins in Uropathogenic Escherichia coli
Principal Advisor
-
2011
Doctor Philosophy
Molecular characterisation of asymptomatic bacteriuria Escherichia coli
Principal Advisor
-
2011
Doctor Philosophy
Identification and characterisation of novel surface proteins of the urinary tract pathogen Staphylococcus saprophyticus
Principal Advisor
Other advisors: Associate Professor Scott Beatson
-
2009
Doctor Philosophy
Identification and Characterisation of Novel Autotransporters of Enterohaemorrhagic Escherichia coli O157:H7
Principal Advisor
-
2009
Doctor Philosophy
Bacterial Aggregation and Biofilm Formation by Uropathogenic Escherichia coli
Principal Advisor
-
2024
Master Philosophy
Theoretical investigations of integron evolution in bacteria
Associate Advisor
Other advisors: Associate Professor Jan Engelstaedter
-
2024
Doctor Philosophy
Application of Transposon Directed Insertion Site Sequencing to Enhance Understanding of Essential Genes in Escherichia coli
Associate Advisor
Other advisors: Professor Ian Henderson
-
2023
Doctor Philosophy
Characterisation of the macrophage zinc toxicity response as an antimicrobial weapon
Associate Advisor
Other advisors: Professor Matt Sweet
-
2022
Doctor Philosophy
Understanding Roles of Commonly Prescribed Antidepressants in the Dissemination of Antibiotic Resistance
Associate Advisor
Other advisors: Professor Jianhua Guo
-
2022
Doctor Philosophy
A bitter taste in your heart: the role of T2Rs in cardiovascular physiology and pathophysiology
Associate Advisor
Other advisors: Professor Mark Walker, Professor Wally Thomas
-
2021
Doctor Philosophy
Characterising B1 Metallo-ß-Lactamases (MBLs)
Joint Principal Advisor
Other advisors: Professor Gary Schenk
-
2019
Doctor Philosophy
Investigation of innate immune antimicrobial zinc toxicity
Associate Advisor
Other advisors: Professor Matt Sweet
-
2019
Doctor Philosophy
Characterization of interactions between uropathogenic Escherichia coli and the innate immune system
Associate Advisor
Other advisors: Professor Matt Sweet
-
2019
Doctor Philosophy
Application of whole genome sequencing to characterise clinically significant multidrug resistant bacteria
Associate Advisor
Other advisors: Associate Professor Scott Beatson
-
2017
Doctor Philosophy
Bacterial ketol-acid reductoisomerase: structure, catalytic mechanism and thermal stability
Associate Advisor
Other advisors: Professor Bostjan Kobe, Professor Luke Guddat
-
2016
Doctor Philosophy
Preventing canine urinary tract infection (UTI) using an asymptomatic bacteriuria (ASB) Escherichia coli strain
Associate Advisor
Other advisors: Professor Paul Mills
-
2015
Doctor Philosophy
Investigating the host and bacterial factors in cystic fibrosis that promote persistence of infection in the lung.
Associate Advisor
-
2014
Doctor Philosophy
Structural and functional studies of TcpB, a protein involved in Brucella pathogenesis
Associate Advisor
Other advisors: Professor Matt Sweet, Professor Bostjan Kobe
-
2014
Doctor Philosophy
Structural & Functional Characterization of Bacterial TRX-fold proteins
Associate Advisor
Other advisors: Emerita Professor Jenny Martin
-
2013
Doctor Philosophy
Identification and characterization of anti-microbial pathways in human macrophages
Associate Advisor
Other advisors: Professor Kate Stacey, Professor Matt Sweet
-
2007
Doctor Philosophy
FUNCTIONAL CHARACTERISATION OF THE MULTICOPPER OXIDASE FROM Escherichia coli and Salmonella typhimurium
Associate Advisor
Media
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