
Overview
Background
Professor Mark Schembri is a prominent microbiologist with experience in combating the global health crisis presented by multi-drug resistant pathogens. Professor Schembri’s expertise on the virulence of bacterial pathogens and his innovative analysis of biofilm formation aims to improve the outcomes of the >400 million individuals that suffer from urinary tract infections each year across the globe.
Through the application of genetic, genomic and functional studies on uropathogenic E. coli, Professor Schembri has identified targets to reduce the virulence of this pathogen, and will pursue the development of life-saving therapeutic and preventative advances with the assistance of NHMRC, MRFF and ARC grants. Professor Schembri has tracked the rapid emergence and global spread of a virulent, drug-resistant E. coli clone and used genome sequencing to understand its evolution and virulence.
Links: Professor Schembri collaborates with national and international research leaders, including in Denmark, where he was a lecturer. Professor Schembri has strong links with other international experts in his field, including at the Pasteur Institute and the Wellcome Trust Sanger Institute in Cambridge. His research collaborations also span lead groups at UQ and other top Australian institutes, including Griffith and La Trobe Universities.
Membership, Funding and patents: Since 2014, Professor Schembri has been awarded over $15 million in funding from competitive national research funding bodies. He holds provisional patents for the development of novel therapeutic agents and vaccine antigens. He is a Fellow of the American Academy of Microbiology, and is regularly invited to speak at international conferences in his field.
Awards and Communication: Professor Schembri was the recipient of the Frank Fenner Award (2010) and the ASM BacPath Oration Award (2019) for his outstanding original research contribution to the study of Infectious Disease. He was an Australian Research Council Future Fellow (2011-2015) a National Health and Medical Research Council Senior Research Fellow (2016-2020). Professor Schembri is the author of >240 peer-reviewed research manuscripts. He is President of the Australian Society for Microbiology (2022-2026).
Availability
- Professor Mark Schembri is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Monash University
Research impacts
Professor Schembri’s outstanding original work in the field of infectious disease and multi-drug resistant pathogens has led to several key advances in the fight to reduce the prevalence and improve outcomes of urinary tract infections.
Key research outputs: The genomic epidemiology of the most widespread antibiotic resistant uropathogenic E. coli clone allowed its origin and dissemination to be mapped on a global scale. Recent work in Professor Schembri’s group has defined the virulence of this pathogen using advanced genetic, transcriptomic and proteomic methods in conjunction with mouse models of infection. He has also led the use of new treatments to prevent infection by this antibiotic resistant pathogen.
Key capabilities: Professor Schembri has deep expertise in microbiology, with particular capability in the study of antibiotic resistant Gram-negative bacterial pathogens and high-throughput modelling of drug-resistant biofilms, as well as the application of forefront technologies to examine virulence, genomic epidemiology, host-pathogen interactions and novel strategies for the treatment/prevention of infectious diseases.
Works
Search Professor Mark Schembri’s works on UQ eSpace
2012
Journal Article
Molecular characterization of UpaB and UpaC, two new autotransporter proteins of uropathogenic Escherichia coli CFT073
Allsopp, Luke P., Beloin, Christophe, Ulett, Glen C., Valle, Jaione, Totsika, Makrina, Sherlock, Orla, Ghigo, Jean-Marc and Schembri, Mark A. (2012). Molecular characterization of UpaB and UpaC, two new autotransporter proteins of uropathogenic Escherichia coli CFT073. Infection and Immunity, 80 (1), 321-332. doi: 10.1128/IAI.05322-11
2012
Journal Article
Immersing undergraduate students in the research experience: A practical laboratory module on molecular cloning of microbial genes
Wang, Jack T.H., Schembri, Mark A., Ramakrishna, Mathitha, Sagulenko, Evgeny and Fuerst, John A. (2012). Immersing undergraduate students in the research experience: A practical laboratory module on molecular cloning of microbial genes. Biochemistry and Molecular Biology Education, 40 (1), 37-45. doi: 10.1002/bmb.20572
2012
Journal Article
Contribution of siderophore systems to growth and urinary tract colonization of asymptomatic bacteriuria Escherichia coli
Watts, Rebecca E., Totsika, Makrina, Challinor, Victoria L., Mabbett, Amanda N., Ulett, Glen C., De Voss, James J. and Schembri, Mark A. (2012). Contribution of siderophore systems to growth and urinary tract colonization of asymptomatic bacteriuria Escherichia coli. Infection and Immunity, 80 (1-2), 333-344. doi: 10.1128/IAI.05594-11
2012
Conference Publication
Effect of Escherichia coli lipopolysaccharide on stretch-induced ATP release from cultured urothelial cells
Mansfield, K., Moore, K. H., Cheng, Y. and Schembri, M. (2012). Effect of Escherichia coli lipopolysaccharide on stretch-induced ATP release from cultured urothelial cells. 42nd Annual Meeting of the International-Continence-Society (ICS), Beijing, China, 15-19 October 2012. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/nau.22287
2011
Journal Article
Molecular characterization of Escherichia coli strains that cause symptomatic and asymptomatic urinary tract infections
Abraham, Sam, Chapman, Toni A., Zhang, Ren, Chin, James, Mabbett, Amanda N., Totsika, Makrina and Schembri Mark A. (2011). Molecular characterization of Escherichia coli strains that cause symptomatic and asymptomatic urinary tract infections. Journal of Clinical Microbiology, 50 (3), 1027-1030. doi: 10.1128/JCM.06671-11
2011
Journal Article
Intramacrophage survival of uropathogenic Escherichia coli: differences between diverse clinical isolates and between mouse and human macrophages
Bokil, Nilesh J., Totsika, Makrina, Carey, Alison J., Stacey, Katryn J., Hancock, Viktoria, Saunders, Bernadette M., Ravasi, Timothy, Ulett, Glenn C., Schembri, Mark A. and Sweet, Matthew J. (2011). Intramacrophage survival of uropathogenic Escherichia coli: differences between diverse clinical isolates and between mouse and human macrophages. Immunobiology, 216 (11), 1164-1171. doi: 10.1016/j.imbio.2011.05.011
2011
Journal Article
Insights into a multidrug resistant escherichia coli pathogen of the globally disseminated ST131 lineage: Genome analysis and virulence mechanisms
Totsika, Makrina, Beatson, Scott A., Sarkar, Sohinee, Phan, Minh-Duy, Petty, Nicola K., Bachmann, Nathan, Szubert, Marek, Sidjabat, Hanna E., Paterson, David L., Upton, Mathew and Schembri, Mark A. (2011). Insights into a multidrug resistant escherichia coli pathogen of the globally disseminated ST131 lineage: Genome analysis and virulence mechanisms. Plos One, 6 (10) e26578, e26578-1-e26578-11. doi: 10.1371/journal.pone.0026578
2011
Journal Article
MrkH, a novel c-di-GMP-dependent transcriptional activator, controls Klebsiella pneumoniae biofilm formation by regulating type 3 fimbriae expression
Wilksch, Jonathan J., Yang, Ji, Clements, Abigail, Gabbe, Jacinta L., Short, Kirsty R., Cao, Hanwei, Cavaliere, Rosalia, James, Catherine E., Whitchurch, Cynthia B., Schembri, Mark A., Chuah, Mary L. C., Liang, Zhao-Xun, Wijburg, Odilia L., Jenney, Adam W., Lithgow, Trevor and Strugnell, Richard A. (2011). MrkH, a novel c-di-GMP-dependent transcriptional activator, controls Klebsiella pneumoniae biofilm formation by regulating type 3 fimbriae expression. PloS Pathogens, 7 (8) e1002204, e1002204. doi: 10.1371/journal.ppat.1002204
2011
Journal Article
The essential beta-barrel assembly machinery complex components BamD and BamA are required for autotransporter biogenesis
Rossiter, Amanda E., Leyton, Denisse L., Tveen-Jensen, Karina, Browning, Douglas F., Sevastsyanovich, Yanina, Knowles, Timothy J., Nichols, Katie B., Cunningham, Adam F., Overduin, Michael, Schembri, Mark A. and Henderson, Ian R. (2011). The essential beta-barrel assembly machinery complex components BamD and BamA are required for autotransporter biogenesis. Journal of Bacteriology, 193 (16), 4250-4253. doi: 10.1128/JB.00192-11
2011
Journal Article
Characterization of EhaJ, a new autotransporter protein from enterohemorrhagic and enteropathogenic Escherichia coli
Easton, Donna M., Totsika, Makrina, Allsopp, Luke P., Phan, Minh-Duy, Idris, Adi, Wurpel, Daniël J., Sherlock, Orla, Zhang, Bing, Venturini, Carola, Beatson, Scott A., Mahony, Timothy J., Cobbold, Rowland N. and Schembri, Mark A. (2011). Characterization of EhaJ, a new autotransporter protein from enterohemorrhagic and enteropathogenic Escherichia coli. Frontiers in Microbiology: Frontiers in Cellular and Infection Microbiology, 2 (JUNE), 120.1-120.9. doi: 10.3389/fmicb.2011.00120
2011
Journal Article
Comparative Genomics of Escherichia coli Strains Causing Urinary Tract Infections
Vejborg, Rebecca Munk, Hancock, Viktoria, Schembri, Mark A. and Klemm, Per (2011). Comparative Genomics of Escherichia coli Strains Causing Urinary Tract Infections. Applied and Environmental Microbiology, 77 (10), 3268-3278. doi: 10.1128/AEM.02970-10
2011
Journal Article
Structure and function of DsbA, a key bacterial oxidative folding catalyst
Shouldice, Stephen R., Heras, Begona, Walden, Patricia M., Totsika, Makrina, Schembri, Mark A. and Martin, Jennifer L. (2011). Structure and function of DsbA, a key bacterial oxidative folding catalyst. Antioxidants and Redox Signaling, 14 (9), 1729-1760. doi: 10.1089/ars.2010.3344
2011
Journal Article
UafB is a serine-rich repeat adhesin of Staphylococcus saprophyticus that mediates binding to fibronectin, fibrinogen and human uroepithelial cells
King, Nathan P., Beatson, Scott A., Totsika, Makrina, Ulett, Glen C., Alm, Richard A., Manning, Paul A. and Schembri, Mark A. (2011). UafB is a serine-rich repeat adhesin of Staphylococcus saprophyticus that mediates binding to fibronectin, fibrinogen and human uroepithelial cells. Microbiology, 157 (4), 1161-1175. doi: 10.1099/mic.0.047639-0
2011
Journal Article
Muramidases found in the foregut microbiome of the Tammar wallaby can direct cell aggregation and biofilm formation
Pope, Phillip B., Totsika, Makrina, de Carcer, Daniel Aguirre, Schembri, Mark A. and Morrison, Mark (2011). Muramidases found in the foregut microbiome of the Tammar wallaby can direct cell aggregation and biofilm formation. ISME Journal, 5 (2), 341-350. doi: 10.1038/ismej.2010.116
2011
Journal Article
Experimental colonization of the canine urinary tract with the asymptomatic bacteriuria Escherichia coli strain 83972
Thompson, Mary F., Totsika, Makrina, Schembri, Mark A., Mills, Paul C., Seton, Erica J. and Trott, Darren J. (2011). Experimental colonization of the canine urinary tract with the asymptomatic bacteriuria Escherichia coli strain 83972. Veterinary Microbiology, 147 (1-2), 205-208. doi: 10.1016/j.vetmic.2010.06.007
2011
Conference Publication
Developing professional research practice in students through undergraduate research experiences
Wang, J. T. H., Schembri, M. A. and Fuerst, J. A. (2011). Developing professional research practice in students through undergraduate research experiences. Higher Education Research and Development (HERDSA 2011), Gold Coast , QLD, Australia, 4-7 July 2011.
2011
Journal Article
Epithelial cell coculture models for studying infectious diseases: Benefits and limitations
Duell, Benjamin, Cripps, Allan W., Schembri, Mark A. and Ulett, Glen C. (2011). Epithelial cell coculture models for studying infectious diseases: Benefits and limitations. Journal of Biomedicine and Biotechnology, 2011 (1) 852419, 1-9. doi: 10.1155/2011/852419
2011
Conference Publication
Undergraduate research experiences: A case study in promoting student engagement through authentic scientific enquiry
Wang, J. T. H., Schembri, M. A., Ramakrishna, M., Sagulenko, E. and Fuerst, J. A. (2011). Undergraduate research experiences: A case study in promoting student engagement through authentic scientific enquiry. Australian Conference on Science and Mathematics Education, University of Melbourne, Melbourne, Australia, 28/9/2011 - 30/9/2011.
2011
Conference Publication
A modified three-dose inoculation protocol for colonisation of the canine urinary tract with the asymptomatic bacteriuria Escherichia coli strain 83972
Thompson, M. F., Mills, P. C., Schembri, M. A. and Trott, D. J. (2011). A modified three-dose inoculation protocol for colonisation of the canine urinary tract with the asymptomatic bacteriuria Escherichia coli strain 83972. Australian College of Veterinary Scientists College Science Week, Gold Coast, QLD, Australia, 30 June- 2 July 2011. Sydney , Australia:
2011
Conference Publication
A modified three-dose inoculation protocol for colonisation of the canine urinary tract with the asymptomatic bacteriuria Escherichia coli strain 83972
Thompson, M.F., Mills, P.C., Schembri, M.A. and Trott, D.J. (2011). A modified three-dose inoculation protocol for colonisation of the canine urinary tract with the asymptomatic bacteriuria Escherichia coli strain 83972. Australian College of Veterinary Scientists - Science Week 2011, Gold Coast, QLD, Australia, 30 June- 2 July. Sydney, NSW, Australia:
Funding
Current funding
Past funding
Supervision
Availability
- Professor Mark Schembri is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
How bacteria form antibiotic resistant biofilms
Principal Advisor
Other advisors: Dr Nhu Nguyen, Dr Duy Phan
-
Doctor Philosophy
Diversity, regulation and function of the uropathogenic Escherichia coli capsule
Principal Advisor
Other advisors: Professor Matt Sweet, Dr Duy Phan
-
Doctor Philosophy
Understanding virulence factors and their regulation in uropathogenic Escherichia coli (UPEC)
Principal Advisor
Other advisors: Dr Nhu Nguyen
-
Doctor Philosophy
Application of Transposon Directed Insertion Site Sequencing to Enhance Understanding of Essential Genes in Escherichia coli
Associate Advisor
Other advisors: Professor Ian Henderson
-
Doctor Philosophy
Identifying new targets for treatment of antimicrobial resistant infections
Associate Advisor
Other advisors: Professor Ian Henderson
-
Doctor Philosophy
Boosting innate immune defence to combat antibiotic-resistant bacterial infections
Associate Advisor
Other advisors: Dr Divya Ramnath, Professor Matt Sweet
-
Doctor Philosophy
Application of Transposon Directed Insertion Site Sequencing to Enhance Understanding of Essential Genes in Escherichia coli
Associate Advisor
Other advisors: Professor Ian Henderson
-
Doctor Philosophy
Genomic and molecular characterisation of antibiotic resistance mechanisms
Associate Advisor
Other advisors: Dr Brian Forde
-
Doctor Philosophy
Microbial effects on host mitochondrial DNA
Associate Advisor
Other advisors: Associate Professor Steven Zuryn
Completed supervision
-
2024
Doctor Philosophy
Understanding virulence factors and their regulation in uropathogenic Escherichia coli (UPEC)
Principal Advisor
Other advisors: Dr Nhu Nguyen
-
2024
Doctor Philosophy
Understanding antibiotic resistance and virulence in uropathogenic Escherichia coli
Principal Advisor
Other advisors: Dr Duy Phan
-
2023
Doctor Philosophy
Understanding the regulation of biofilm matrix components in uropathogenic Escherichia coli virulence
Principal Advisor
Other advisors: Dr Nhu Nguyen
-
2023
Doctor Philosophy
Virulence and Resistance Plasmids of Extra-intestinal Pathogenic Escherichia coli
Principal Advisor
Other advisors: Dr Duy Phan
-
2022
Doctor Philosophy
Characterisation of Escherichia coli fimbrial and autotransporter adhesins
Principal Advisor
Other advisors: Dr Duy Phan
-
2019
Doctor Philosophy
Molecular characterisation of A/C plasmids
Principal Advisor
Other advisors: Dr Duy Phan
-
2018
Doctor Philosophy
Molecular and genomic analysis of multidrug resistant Uropathogenic Escherichia coli
Principal Advisor
Other advisors: Associate Professor Scott Beatson
-
2017
Doctor Philosophy
Characterisation of flagella and resistance to oxidative stress in Escherichia coli ST131 virulence
Principal Advisor
-
2017
Doctor Philosophy
Characterisation of Factors Involved in Escherichia coli Virulence: Type Ve Inverse Autotransporter Proteins and the K1 Capsule
Principal Advisor
-
2016
Master Philosophy
Autotransporter Proteins of Uropathogenic Escherichia coli: Regulation, Characterisation and the Role of Periplasmic Proteins in their Expression
Principal Advisor
-
2016
Doctor Philosophy
Uropathogenic Escherichia coli: Towards a Better Understanding through the Characterisation of a Vaccine Antigen and Virulence Factor
Principal Advisor
-
2014
Doctor Philosophy
Evolutionary Phylogeny and Molecular Characterisation of Chaperone-Usher Fimbriae from Uropathogenic Escherichia coli
Principal Advisor
-
2014
Doctor Philosophy
Investigating the Virulence Potential of the Multidrug Resistant Uropathogenic Escherichia coli ST131 clone
Principal Advisor
Other advisors: Associate Professor Scott Beatson
-
2012
Doctor Philosophy
Molecular analysis of Acinetobacter baumannii isolates from an intensive care unit
Principal Advisor
Other advisors: Associate Professor Scott Beatson
-
2011
Doctor Philosophy
Identification and Characterisation of New Adhesins in Uropathogenic Escherichia coli
Principal Advisor
-
2011
Doctor Philosophy
Molecular characterisation of asymptomatic bacteriuria Escherichia coli
Principal Advisor
-
2011
Doctor Philosophy
Identification and characterisation of novel surface proteins of the urinary tract pathogen Staphylococcus saprophyticus
Principal Advisor
Other advisors: Associate Professor Scott Beatson
-
2009
Doctor Philosophy
Identification and Characterisation of Novel Autotransporters of Enterohaemorrhagic Escherichia coli O157:H7
Principal Advisor
-
2009
Doctor Philosophy
Bacterial Aggregation and Biofilm Formation by Uropathogenic Escherichia coli
Principal Advisor
-
2024
Master Philosophy
Theoretical investigations of integron evolution in bacteria
Associate Advisor
Other advisors: Associate Professor Jan Engelstaedter
-
2024
Doctor Philosophy
Application of Transposon Directed Insertion Site Sequencing to Enhance Understanding of Essential Genes in Escherichia coli
Associate Advisor
Other advisors: Professor Ian Henderson
-
2023
Doctor Philosophy
Characterisation of the macrophage zinc toxicity response as an antimicrobial weapon
Associate Advisor
Other advisors: Professor Matt Sweet
-
2022
Doctor Philosophy
A bitter taste in your heart: the role of T2Rs in cardiovascular physiology and pathophysiology
Associate Advisor
Other advisors: Professor Mark Walker, Professor Wally Thomas
-
2022
Doctor Philosophy
Understanding Roles of Commonly Prescribed Antidepressants in the Dissemination of Antibiotic Resistance
Associate Advisor
Other advisors: Professor Jianhua Guo
-
2021
Doctor Philosophy
Characterising B1 Metallo-ß-Lactamases (MBLs)
Joint Principal Advisor
Other advisors: Professor Gary Schenk
-
2019
Doctor Philosophy
Investigation of innate immune antimicrobial zinc toxicity
Associate Advisor
Other advisors: Professor Matt Sweet
-
2019
Doctor Philosophy
Characterization of interactions between uropathogenic Escherichia coli and the innate immune system
Associate Advisor
Other advisors: Professor Matt Sweet
-
2019
Doctor Philosophy
Application of whole genome sequencing to characterise clinically significant multidrug resistant bacteria
Associate Advisor
Other advisors: Associate Professor Scott Beatson
-
2017
Doctor Philosophy
Bacterial ketol-acid reductoisomerase: structure, catalytic mechanism and thermal stability
Associate Advisor
Other advisors: Professor Bostjan Kobe, Professor Luke Guddat
-
2016
Doctor Philosophy
Preventing canine urinary tract infection (UTI) using an asymptomatic bacteriuria (ASB) Escherichia coli strain
Associate Advisor
Other advisors: Professor Paul Mills
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2015
Doctor Philosophy
Investigating the host and bacterial factors in cystic fibrosis that promote persistence of infection in the lung.
Associate Advisor
-
2014
Doctor Philosophy
Structural and functional studies of TcpB, a protein involved in Brucella pathogenesis
Associate Advisor
Other advisors: Professor Matt Sweet, Professor Bostjan Kobe
-
2014
Doctor Philosophy
Structural & Functional Characterization of Bacterial TRX-fold proteins
Associate Advisor
Other advisors: Emerita Professor Jenny Martin
-
2013
Doctor Philosophy
Identification and characterization of anti-microbial pathways in human macrophages
Associate Advisor
Other advisors: Professor Kate Stacey, Professor Matt Sweet
-
2007
Doctor Philosophy
FUNCTIONAL CHARACTERISATION OF THE MULTICOPPER OXIDASE FROM Escherichia coli and Salmonella typhimurium
Associate Advisor
Media
Enquiries
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