
Overview
Background
Brett Collins is an NHMRC Career Development Fellow and head of the Molecular Trafficking Lab at UQ's Institute for Molecular Bioscience. He was a lead investigator in the seminal structural studies of AP2, the protein adaptor molecule central to clathrin-mediated endocytosis, and has since defined the molecular basis for the function of critical proteins regulating membrane trafficking and signalling at the endosome organelle. His team is now focused on understanding how discrete molecular interactions between proteins and lipids control these processes in human cells.
Associate Professor Collins was awarded his PhD in 2001 and has published over 75 papers including in Cell, Nature, Nature Structural and Molecular Biology, Developmental Cell, and The Proceedings of the National Academy of Sciences USA, altogether cited more than 3100 times. He is the recipient of 3 prestigious fellowships, including a previous Career Development Award from the National Health and Medical Research Council and a Future Fellowship from the Australian Research Council, and was awarded the University of Queensland Research Excellence Award in 2008. In 2015 he was awarded the Emerging Leader Award of the ANZSCDB and in 2016 the Merck Research Medal from the ASBMB. He is currently the President of the Queensland Protein Group.
Availability
- Professor Brett Collins is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, Macquarie University
Research interests
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Membrane Trafficking
The basis for movement of molecules between cellular organelles essential for cell homeostasis.
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Structural biology
The atomic resolution details of how biological molecules are assembled together and interact with each other.
Research impacts
Trafficking is essential for normal cellular function and is perturbed in many different diseases, notably Alzheimer’s and other neurological disorders, pathogen invasion, cancer and inflammation. A/Prof Collins is probing the fundamental mechanisms of membrane transport, through the application of high-resolution structure determination, quantitative biophysical analyses of molecular interactions, and correlated cellular studies of essential protein machineries. Understanding these molecular mechanisms will allow us to determine how their dysfunction contributes to disease and how to target them for new therapies.
Works
Search Professor Brett Collins’s works on UQ eSpace
2019
Journal Article
Downregulation of SNX27 expression does not exacerbate amyloidogenesis in the APP/PS1 Alzheimer's disease mouse model
Milne, Michael R., Qian, Lei, Turnbull, Marion T., Kinna, Genevieve, Collins, Brett M., Teasdale, Rohan D. and Coulson, Elizabeth J. (2019). Downregulation of SNX27 expression does not exacerbate amyloidogenesis in the APP/PS1 Alzheimer's disease mouse model. Neurobiology of Aging, 77, 144-153. doi: 10.1016/j.neurobiolaging.2019.01.011
2019
Journal Article
Elucidating the lipid binding properties of membrane-active peptides using cyclised nanodiscs
Zhang, Alan H., Edwards, Ingrid A., Mishra, Biswa P., Sharma, Gagan, Healy, Michael D., Elliott, Alysha, Blaskovich, Mark A. T., Cooper, Matthew A., Collins, Brett M., Jia, Xinying and Mobli, Mehdi (2019). Elucidating the lipid binding properties of membrane-active peptides using cyclised nanodiscs. Frontiers in Chemistry, 7 (MAR) 238, 238. doi: 10.3389/fchem.2019.00238
2019
Journal Article
Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities
Chandra, Mintu, Chin, Yanni K.-Y., Mas, Caroline, Feathers, J. Ryan, Paul, Blessy, Datta, Sanchari, Chen, Kai-En, Jia, Xinying, Yang, Zhe, Norwood, Suzanne J., Mohanty, Biswaranjan, Bugarcic, Andrea, Teasdale, Rohan D., Henne, W. Mike, Mobli, Mehdi and Collins, Brett M. (2019). Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities. Nature Communications, 10 (1) 1528, 1528. doi: 10.1038/s41467-019-09355-y
2018
Journal Article
Molecular basis for membrane recruitment by the PX and C2 domains of Class II Phosphoinositide 3-Kinase-C2α
Chen, Kai-En, Tillu, Vikas A., Chandra, Mintu and Collins, Brett M. (2018). Molecular basis for membrane recruitment by the PX and C2 domains of Class II Phosphoinositide 3-Kinase-C2α. Structure, 26 (12), 1612-1625.e4. doi: 10.1016/j.str.2018.08.010
2018
Journal Article
Structure of the membrane-assembled retromer coat determined by cryo-electron tomography
Kovtun, Oleksiy, Leneva, Natalya, Bykov, Yury S., Ariotti, Nicholas, Teasdale, Rohan D., Schaffer, Miroslava, Engel, Benjamin D., Owen, David. J., Briggs, John A. G. and Collins, Brett M. (2018). Structure of the membrane-assembled retromer coat determined by cryo-electron tomography. Nature, 561 (7724), 561-+. doi: 10.1038/s41586-018-0526-z
2018
Journal Article
A variable undecad repeat domain in cavin1 regulates caveola formation and stability
Tillu, Vikas A., Lim, Ye-Wheen, Kovtun, Oleksiy, Mureev, Sergey, Ferguson, Charles, Bastiani, Michele, McMahon, Kerrie-Ann, Lo, Harriet P., Hall, Thomas E., Alexandrov, Kirill, Collins, Brett M. and Parton, Robert G. (2018). A variable undecad repeat domain in cavin1 regulates caveola formation and stability. EMBO Reports, 19 (9) e45775. doi: 10.15252/embr.201845775
2018
Journal Article
Structural insights into the architecture and membrane interactions of the conserved COMMD proteins
Healy, Michael D., Hospenthal, Manuela K., Hall, Ryan J., Chandra, Mintu, Chilton, Molly, Tillu, Vikas, Chen, Kai-En, Celligoi, Dion J., McDonald, Fiona J., Cullen, Peter J., Lott, J. Shaun, Collins, Brett M. and Ghai, Rajesh (2018). Structural insights into the architecture and membrane interactions of the conserved COMMD proteins. eLife, 7 e35898. doi: 10.7554/elife.35898
2018
Journal Article
SNT-1 functions as the Ca2+ sensor for tonic and evoked neurotransmitter release in Caenorhabditis Elegans
Li, Lei, Liu, Haowen, Wang, Wei, Chandra, Mintu, Collins, Brett M. and Hu, Zhitao (2018). SNT-1 functions as the Ca2+ sensor for tonic and evoked neurotransmitter release in Caenorhabditis Elegans. The Journal of Neuroscience, 38 (23), 5313-5324. doi: 10.1523/JNEUROSCI.3097-17.2018
2018
Conference Publication
Characterisation of protein complexes essential to cellular trafficking
Livingstone, Emma, Whitten, Andrew, Weeratunga, Saroja, Martin, Jennifer and Collins, Brett (2018). Characterisation of protein complexes essential to cellular trafficking. 32nd Annual Symposium of the Protein Society, Boston, MA, 9-12 July 2018 . Hoboken, NJ, United States: Wiley-Blackwell.
2018
Other Outputs
X-ray diffraction images related to PDB file 6E8R
Collins, Brett (2018). X-ray diffraction images related to PDB file 6E8R. The University of Queensland. (Dataset) doi: 10.14264/uql.2018.497
2017
Journal Article
SNX27 links DGKζ to the control of transcriptional and metabolic programs in T lymphocytes
Tello-Lafoz, M., Rodríguez-Rodríguez, C., Kinna, G., Loo, L. S., Hong, W., Collins, B. M., Teasdale, R. D. and Mérida, I. (2017). SNX27 links DGKζ to the control of transcriptional and metabolic programs in T lymphocytes. Scientific Reports, 7 (1) 16361, 1-14. doi: 10.1038/s41598-017-16370-w
2017
Journal Article
Revisiting interaction specificity reveals neuronal and adipocyte Munc18 membrane fusion regulatory proteins differ in their binding interactions with partner SNARE Syntaxins
Christie, Michelle P., Hu, Shu-Hong, Whitten, Andrew E., Rehman, Asma, Jarrott, Russell J., King, Gordon J., Collins, Brett M. and Martin, Jennifer L. (2017). Revisiting interaction specificity reveals neuronal and adipocyte Munc18 membrane fusion regulatory proteins differ in their binding interactions with partner SNARE Syntaxins. PloS one, 12 (10) e0187302, 1-16. doi: 10.1371/journal.pone.0187302
2017
Journal Article
Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling
McNally, Kerrie E., Faulkner, Rebecca, Steinberg, Florian, Gallon, Matthew, Ghai, Rajesh, Pim, David, Langton, Paul, Pearson, Neil, Danson, Chris M., Nägele, Heike, Morris, Lindsey L., Singla, Amika, Overlee, Brittany L., Heesom, Kate J., Sessions, Richard, Banks, Lawrence, Collins, Brett M., Berger, Imre, Billadeau, Daniel D., Burstein, Ezra and Cullen, Peter J. (2017). Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling. Nature cell biology, 19 (10), 1214-1225. doi: 10.1038/ncb3610
2017
Journal Article
Origins of PDZ binding specificity. A computational and experimental study using NHERF1 and the parathyroid hormone receptor
Mamonova, Tatyana, Zhang, Qiangmin, Chandra, Mintu, Collins, Brett M., Sarfo, Edward, Bu, Zimei, Xiao, Kunhong, Bisello, Alessandro and Friedman, Peter A. (2017). Origins of PDZ binding specificity. A computational and experimental study using NHERF1 and the parathyroid hormone receptor. Biochemistry, 56 (20), 2584-2593. doi: 10.1021/acs.biochem.7b00078
2017
Conference Publication
Structural basis for the hijacking of endosomal sorting nexin proteins by Chlamydia trachomatis
Paul, B., Kim, H. S., Kerr, M. C., Huston, W. M., Teasdale, R. D. and Collins, B. M. (2017). Structural basis for the hijacking of endosomal sorting nexin proteins by Chlamydia trachomatis. Annual Joint Meeting of the American Society for Cell Biology and the European Molecular Biology Organization (ASCB/EMBO), Philadelphia, PA United States, 2-6 December 2017. Bethesda, MD United States: American Society for Cell Biology.
2016
Journal Article
The Munc18-1 domain 3a hinge-loop controls syntaxin-1A nanodomain assembly and engagement with the SNARE complex during secretory vesicle priming
Kasula, Ravikiran, Chai, Ye Jin, Bademosi, Adekunle T., Harper, Callista B., Gormal, Rachel S., Morrow, Isabel C., Hosy, Eric, Collins, Brett M., Choquet, Daniel, Papadopulos, Andreas and Meunier, Frederic A. (2016). The Munc18-1 domain 3a hinge-loop controls syntaxin-1A nanodomain assembly and engagement with the SNARE complex during secretory vesicle priming. The Journal of Cell Biology, 214 (7) 847, 847-858. doi: 10.1083/jcb.201508118
2016
Journal Article
A molecular code for endosomal recycling of phosphorylated cargos by the SNX27–retromer complex
Clairfeuille, Thomas, Mas, Caroline, Chan, Audrey S. M., Yang, Zhe, Tello-Lafoz, Maria, Chandra, Mintu, Wigagdo, Jocelyn, Kerr, Markus, Blessy, Paul, Merida, Isabel, Teasdale, Rohan D., Pavlos, Nathan J., Anggono, Victor and Collins, Brett (2016). A molecular code for endosomal recycling of phosphorylated cargos by the SNX27–retromer complex. Nature Structural and Molecular Biology, 23 (10), 921-932. doi: 10.1038/nsmb.3290
2016
Journal Article
Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation
Chai, Ye Jin, Sierecki, Emma, Tomatis, Vanesa M., Gormal, Rachel S., Giles, Nichole, Morrow, Isabel C., Xia, Di, Götz, Jürgen, Parton, Robert G., Collins, Brett M., Gambin, Yann and Meunier, Frédéric A. (2016). Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation. The Journal of Cell Biology, 214 (6) 705, 705-718. doi: 10.1083/jcb.201512016
2016
Journal Article
Parkinson disease-linked Vps35 R524W mutation impairs the endosomal association of retromer and induces α-synuclein aggregation
Follett, Jordan, Bugarcic, Andrea, Yang, Zhe, Ariotti, Nicholas, Norwood, Suzanne J., Collins, Brett M., Parton, Robert G. and Teasdale, Rohan D. (2016). Parkinson disease-linked Vps35 R524W mutation impairs the endosomal association of retromer and induces α-synuclein aggregation. Journal of Biological Chemistry, 291 (35), 18283-18298. doi: 10.1074/jbc.M115.703157
2016
Journal Article
Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins
McMillan, Kirsty J., Gallon, Matthew, Jellett, Adam P., Clairfeuille, Thomas, Tilley, Frances C., McGough, Ian, Danson, Chris M., Heesom, Kate J., Wilkinson, Kevin A., Collins, Brett M. and Cullen, Peter J. (2016). Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins. Journal of Cell Biology, 214 (4), 389-399. doi: 10.1083/jcb.201604057
Funding
Current funding
Past funding
Supervision
Availability
- Professor Brett Collins is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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High resolution structural studies of the Commander protein complex essential for intracellular trafficking
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Developing synthetic nanobodies for high resolution structural studies
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Structure and function of endosomal sorting nexin proteins.
Supervision history
Current supervision
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Doctor Philosophy
Studying the role of the Retromer trafficking complex as a hub for regulating Rab GTPases at the endosome.
Principal Advisor
Other advisors: Dr Kevin Chen
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Doctor Philosophy
Studying the role of Calsyntenin-1 as a novel chaperone for the amyloid precursor protein.
Principal Advisor
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Doctor Philosophy
Structural and cellular analysis of Rab GTPases for drug development in cancer.
Principal Advisor
Other advisors: Professor Jennifer Stow, Dr Quan Nguyen
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Doctor Philosophy
Targeting bacterial cell envelope coordination for antibiotic drug discovery
Associate Advisor
Other advisors: Professor Waldemar Vollmer
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Doctor Philosophy
Characterisation of The Role of Caveolar Coat Proteins in Breast Cancer
Associate Advisor
Other advisors: Dr Harriet Lo, Professor Robert Parton
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Doctor Philosophy
Characterization of blood-brain barrier nutrient transporters
Associate Advisor
Other advisors: Dr Rosemary Cater
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Doctor Philosophy
Regulation of sorting nexin 27 by protein phosphorylation
Associate Advisor
Other advisors: Associate Professor Victor Anggono
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Doctor Philosophy
Understanding the molecular structures of proteins involved in rare disease.
Associate Advisor
Other advisors: Dr Rosemary Cater
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Doctor Philosophy
Development of peptide-based inhibitors for crop protection
Associate Advisor
Other advisors: Dr Conan Wang, Professor David Craik
Completed supervision
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2025
Doctor Philosophy
Exploring connections between mitochondrial fission and lipid droplets in macrophage antimicrobial responses.
Principal Advisor
Other advisors: Professor Jennifer Stow
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2023
Doctor Philosophy
Structural Studies of Cavin Complex Formation and Interaction with Regulatory Proteins
Principal Advisor
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2023
Doctor Philosophy
Structural Characterisation of Endosomal Trafficking Protein Sorting Nexin 27
Principal Advisor
Other advisors: Dr Kevin Chen
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2021
Doctor Philosophy
Screening ligand-binding domains for rapid biosensor design and testing
Principal Advisor
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2021
Doctor Philosophy
Structural and Functional Characterisation of the Commander Trafficking Complex and Accessory Proteins
Principal Advisor
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2021
Doctor Philosophy
Rational computational design of protein binders for biosensor and therapeutic applications
Principal Advisor
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2020
Doctor Philosophy
E. coli Cell-Free Platform for Production of Complex Peptides and Proteins
Principal Advisor
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2019
Doctor Philosophy
Structural studies of sorting nexin proteins from two distinct subfamilies
Principal Advisor
Other advisors: Associate Professor Rohan Teasdale
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2019
Doctor Philosophy
Characterisation of proteins essential to vesicle membrane fusion
Principal Advisor
Other advisors: Emerita Professor Jenny Martin
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2019
Doctor Philosophy
Structural and functional studies of suppressor of copper sensitivity proteins from Proteus mirabilis
Principal Advisor
Other advisors: Emerita Professor Jenny Martin
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2015
Doctor Philosophy
Structural basis of protein cargo transport by sorting nexins
Principal Advisor
Other advisors: Associate Professor Rohan Teasdale
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2013
Doctor Philosophy
Structure-function studies of the PX-FERM proteins in endosomal trafficking
Principal Advisor
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2011
Doctor Philosophy
Structural Basis for Assembly and Membrane Modulating Properties of the Retromer Protein Coat Complex
Principal Advisor
Other advisors: Associate Professor Rohan Teasdale
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2023
Doctor Philosophy
Understanding Protein Mediated Membrane Fusion
Associate Advisor
Other advisors: Professor Alan Mark
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2019
Doctor Philosophy
Characterisation and roles of the postsynaptic Ca2+ sensor Copine-6 in primary neurons
Associate Advisor
Other advisors: Associate Professor Victor Anggono
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2019
Doctor Philosophy
Dynamic re-organisation of Munc18-1 and syntaxin-1A nanodomains on the plasma membrane of neurosecretory cells during exocytosis
Associate Advisor
Other advisors: Professor Frederic Meunier
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2019
Doctor Philosophy
Dynamic Reorganization of Presynaptic Proteins During Neurotransmission and Neuronal Degeneration
Associate Advisor
Other advisors: Professor Jurgen Götz, Professor Frederic Meunier
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2018
Doctor Philosophy
The disulfide oxidative pathway in Chlamydia trachomatis
Associate Advisor
Other advisors: Emerita Professor Jenny Martin
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2016
Doctor Philosophy
Structural and functional characterisation of the cavin membrane coat complex
Associate Advisor
Other advisors: Professor Robert Parton
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2014
Doctor Philosophy
Towards the development of a prokaryotic system for the in vitro study of caveola formation
Associate Advisor
Other advisors: Professor Robert Parton
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2014
Doctor Philosophy
Analysing the Mechanism and Regulation of Vinculin in Cadherin Adhesions
Associate Advisor
Other advisors: Professor Alpha Yap
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2013
Doctor Philosophy
Novel approaches for understanding prenylation and Rho GTPase membrane targeting
Associate Advisor
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2012
Doctor Philosophy
Role of Munc18-1 in regulating neuroexocytosis
Associate Advisor
Other advisors: Professor Elizabeth Coulson, Professor Frederic Meunier
Media
Enquiries
Contact Professor Brett Collins directly for media enquiries about:
- Alzheimer's
- cancer
- Cryoelectron microscopy
- inflammation
- inflammatory disease
- muscular dystrophy
- Parkinson's
- x-ray crystallography
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