Professor Paul Bernhardt
Professor

Paul Bernhardt

Email: 
Phone: 
+61 7 336 54266

Background

After completing my undergraduate and postgraduate studies at the University of Newcastle, I held a Postdoctoral Fellowship at the University of Basel (Switzerland) from 1990-2. I returned to Australia in 1993 to take up an Australian Research Council Postdoctoral Fellowship at the Australian National University (Canberra) from 1993-4. I joined The University of Queensland in 1994.

Availability

Professor Paul Bernhardt is:
Available for supervision
Media expert

Fields of research

Inorganic chemistry Medicinal and biomolecular chemistry

Qualifications

  • Doctor of Philosophy, University of Newcastle

Research interests

  • Protein Electrochemistry

    This research involves incorporating redox active enzymes with electrochemical systems such that the enzyme functions natively whilst in communication with an electrode (rather than with a natural electron transfer partner). We are currently investigating a number of systems, most from the molybdenum enzyme family that catalyse oxygen transfer reactions of both organic and inorganic substrates.

  • Copper Complexes as Atom Transfer Radical Catalysts

    Atom transfer radical polymerisation (ATRP) is one of the most widely used 'controlled' radical polymerisation techniques and has resulted in polymers with well defined molecular weights and architectures. Our work is focused on complexes that catalyse this process by generating organic radicals from the simple reaction between a Cu(I) complex and an alkyl halide initiator. We can probe this atom transfer reaction with cyclic voltammetry and we have gained new insight to this interesting and fundamentally important reaction. This has now progressed to developing electrocatalytic synthetic methods for C-C bond formation reactions in collaboration with Prof. Craig Williams (SCMB).

Research impacts

My research interests include all aspects of coordination chemistry; particularly its relevance to the areas of electrochemistry, bioinorganic chemistry, spectroscopy and catalysis.

In recent years some of the areas in which we have been, and continue to be, actively involved include:

  • Enzyme electrochemistry (collaborations with several UQ and international groups).
  • Invesitigation of copper complexes that are active in atom transfer radical polymerisation catalysis
  • Transition metal-mediated organic oxidation and reduction reactions

Search Professor Paul Bernhardt’s works on UQ eSpace

545 works between 1987 and 2025
All (545) Journal Article (513) Book Chapter (3) Conference Publication (28) Other Outputs (1)

341 - 360 of 545 works

2006

Journal Article

Dimeric allylpalladium(II) complexes with pyrazolate bridges: Synthesis, characterization, structure and thermal behaviour

Singhal, A., Mishra, R., Kulshreshtha, S. K., Bernhardt, P. V. and Tiekink, E. R. T. (2006). Dimeric allylpalladium(II) complexes with pyrazolate bridges: Synthesis, characterization, structure and thermal behaviour. Journal of Organometallic Chemistry, 691 (7), 1402-1410. doi: 10.1016/j.jorganchem.2005.12.037

Dimeric allylpalladium(II) complexes with pyrazolate bridges: Synthesis, characterization, structure and thermal behaviour

2006

Journal Article

Transition metal complexes as mediator-titrants in protein redox potentiometry

Bernhardt, P. V., Chen, K. I. and Sharpe, P. C. (2006). Transition metal complexes as mediator-titrants in protein redox potentiometry. Journal of Biological Inorganic Chemistry, 11 (7), 930-936. doi: 10.1007/s00775-006-0148-z

Transition metal complexes as mediator-titrants in protein redox potentiometry

2006

Journal Article

Direct electrochemically driven catalysis of bovine milk xanthine oxidase

Bernhardt, P. V., Honeychurch, M. J. and McEwan, A. G. (2006). Direct electrochemically driven catalysis of bovine milk xanthine oxidase. Electrochemistry Communications, 8 (2), 257-261. doi: 10.1016/j.elecom.2005.08.009

Direct electrochemically driven catalysis of bovine milk xanthine oxidase

2006

Journal Article

Cobalt complexes of tripodal hexadentate ligands: Electrochemically driven rearrangements

Bernhardt, P. V., Kim, Y. and Sujandi (2006). Cobalt complexes of tripodal hexadentate ligands: Electrochemically driven rearrangements. Australian Journal of Chemistry, 59 (11), 783-790. doi: 10.1071/CH06257

Cobalt complexes of tripodal hexadentate ligands: Electrochemically driven rearrangements

2006

Journal Article

Azedaralide: total synthesis, relative and absolute stereochemical assignment

Baker, L. A., Williams, C. M., Bernhardt, P. V. and Yanik, G. W. (2006). Azedaralide: total synthesis, relative and absolute stereochemical assignment. Tetrahedron, 62 (31), 7355-7360. doi: 10.1016/j.tet.2006.05.030

Azedaralide: total synthesis, relative and absolute stereochemical assignment

2006

Journal Article

Electronic energy-transfer rate constants for geometrical isomers of a bichromophoric macrocyclic complex

Moore, E. G., Bernhardt, P. V., Riley, M. J. and Smith, T. A. (2006). Electronic energy-transfer rate constants for geometrical isomers of a bichromophoric macrocyclic complex. Inorganic Chemistry, 45 (1), 51-58. doi: 10.1021/ic050396l

Electronic energy-transfer rate constants for geometrical isomers of a bichromophoric macrocyclic complex

2006

Journal Article

Isomeric distribution and catalyzed isomerization of cobalt(III) complexes with pentadentate macrocyclic ligands. Importance of hydrogen bonding

Aullon, Gabriel, Bernhardt, Paul V., Bozoglian, Fernando, Font-Bardia, Merce, Macpherson, Brendan P., Martinez, Manuel, Rodriguez, Carlos and Solans, Xavier (2006). Isomeric distribution and catalyzed isomerization of cobalt(III) complexes with pentadentate macrocyclic ligands. Importance of hydrogen bonding. Inorganic Chemistry, 45 (21), 8551-8562. doi: 10.1021/ic060720s

Isomeric distribution and catalyzed isomerization of cobalt(III) complexes with pentadentate macrocyclic ligands. Importance of hydrogen bonding

2006

Journal Article

2-Methoxy-6-methyl-3-nitro-4-(2-nitroprop-1-enyl)phenyl acetate

Moore, E. G., Meredith, P. and Bernhardt, P. V. (2006). 2-Methoxy-6-methyl-3-nitro-4-(2-nitroprop-1-enyl)phenyl acetate. Acta Crystallographica Section E, 61 (6), o1709-o1711. doi: 10.1107/S1600536805014212

2-Methoxy-6-methyl-3-nitro-4-(2-nitroprop-1-enyl)phenyl acetate

2006

Journal Article

Determination of the anomeric configurations of 2,3,4,6-tetra-O-acetyl-D-mannopyranosyl azide

Cosgrove, K. L., Bernhardt, P. V., Ross, B. P. and McGeary, R. P. (2006). Determination of the anomeric configurations of 2,3,4,6-tetra-O-acetyl-D-mannopyranosyl azide. Australian Journal of Chemistry, 59 (2), 473-476. doi: 10.1071/CH06157

Determination of the anomeric configurations of 2,3,4,6-tetra-O-acetyl-D-mannopyranosyl azide

2006

Journal Article

Polyamines from polyols - Pathways to azamacrocycles with hydroxymethyl pendent groups

Bernhardt, P. V., Cho, J. H., Harrowfield, J. M., Kim, J. Y., Kim, Y., Sujandi, Thuery, P. and Yoon, D. C. (2006). Polyamines from polyols - Pathways to azamacrocycles with hydroxymethyl pendent groups. Polyhedron, 25 (8), 1811-1822. doi: 10.1016/j.poly.2005.11.024

Polyamines from polyols - Pathways to azamacrocycles with hydroxymethyl pendent groups

2006

Journal Article

Dinuclear cyano-bridged Co-III-Fe-II complexes as precursors for molecular mixed-valence complexes of higher nuclearity

Bernhardt, P. V., Bozoglian, F., Gonzalez, G., Martinez, M., Macpherson, B. P. and Sienra, B. (2006). Dinuclear cyano-bridged Co-III-Fe-II complexes as precursors for molecular mixed-valence complexes of higher nuclearity. Inorganic Chemistry, 45 (1), 74-82. doi: 10.1021/ic0511423

Dinuclear cyano-bridged Co-III-Fe-II complexes as precursors for molecular mixed-valence complexes of higher nuclearity

2006

Journal Article

Kinetic and structural evidence for the importance of Tyr236 for the integrity of the Mo active site in a bacterial sulfite dehydrogenase

Kappler, U., Bailey, S., Feng, C., Honeychurch, M. J., Hanson, G. R., Bernhardt, P. V., Tollin, G. and Enemark, J. H. (2006). Kinetic and structural evidence for the importance of Tyr236 for the integrity of the Mo active site in a bacterial sulfite dehydrogenase. Biochemistry, 45 (32), 9696-9705. doi: 10.1021/bi060058b

Kinetic and structural evidence for the importance of Tyr236 for the integrity of the Mo active site in a bacterial sulfite dehydrogenase

2006

Journal Article

1,3-Dimethylisoguanine

Panthong, K., Garson, M. J. and Bernhardt, P. V. (2006). 1,3-Dimethylisoguanine. Acta Crystallographica Section C-crystal Structure Communications, 62 (4), O193-O195. doi: 10.1107/S0108270106005336

1,3-Dimethylisoguanine

2005

Journal Article

Synthesis, characterization and X-ray crystal structures of dinuclear nickel(II) complexes of a novel potentially hexadentate but functionally tetradentate binucleating ligand

Akbar Ali, Mohammad, Mirza, A. H., Nazimuddin, Mohamed, Karim, Feroza and Bernhardt, Paul V. (2005). Synthesis, characterization and X-ray crystal structures of dinuclear nickel(II) complexes of a novel potentially hexadentate but functionally tetradentate binucleating ligand. Inorganica Chimica Acta, 358 (15), 4548-4554. doi: 10.1016/j.ica.2005.08.022

Synthesis, characterization and X-ray crystal structures of dinuclear nickel(II) complexes of a novel potentially hexadentate but functionally tetradentate binucleating ligand

2005

Journal Article

Novel diaroylhydrazine ligands as iron chelators: coordination chemistry and biological activity

Bernhardt, Paul V., Chin, Piao, Sharpe, Philip C., Wang, Jing-Yan C. and Richardson, Des R. (2005). Novel diaroylhydrazine ligands as iron chelators: coordination chemistry and biological activity. Journal of Biological Inorganic Chemistry, 10 (7), 761-777. doi: 10.1007/s00775-005-0018-0

Novel diaroylhydrazine ligands as iron chelators: coordination chemistry and biological activity

2005

Conference Publication

Molecular mixed-valence cyanide bridged CoIII-FeII complexes

Bernhardt, Paul V., Bozoglián, Fernando, Macpherson, Brendan P. and Martínez, Manuel (2005). Molecular mixed-valence cyanide bridged CoIII-FeII complexes. doi: 10.1016/j.ccr.2004.11.014

Molecular mixed-valence cyanide bridged CoIII-FeII complexes

2005

Journal Article

Cyanocobalt(III) complexes of penta- and tetradentate-coordinated macrocyclic hexaamines

Bernhardt, Paul V. and Kilah, Nathan L. (2005). Cyanocobalt(III) complexes of penta- and tetradentate-coordinated macrocyclic hexaamines. Acta Crystallographica Section C-crystal Structure Communications, 61 (5), M245-M249. doi: 10.1107/S0108270105009261

Cyanocobalt(III) complexes of penta- and tetradentate-coordinated macrocyclic hexaamines

2005

Journal Article

Pressure and temperature effects on metal-to-metal charge transfer in cyano-bridged Co-III-Fe-II complexes

Macpherson, Brendan P., Alzoubi, Basam M., Bernhardt, Paul V., Martinez, Manuel, Tregloan, Peter A. and van Eldik, Rudi (2005). Pressure and temperature effects on metal-to-metal charge transfer in cyano-bridged Co-III-Fe-II complexes. Dalton Transactions (8), 1459-1467. doi: 10.1039/b418054b

Pressure and temperature effects on metal-to-metal charge transfer in cyano-bridged Co-III-Fe-II complexes

2005

Journal Article

Direct electrochemistry of enzymes from the cytochrome P4502C family

Shukla, Alka, Gillam, Elizabeth M., Mitchell, Deanne J. and Bernhardt, Paul V. (2005). Direct electrochemistry of enzymes from the cytochrome P4502C family. Electrochemistry Communications, 7 (4), 437-442. doi: 10.1016/j.elecom.2005.02.021

Direct electrochemistry of enzymes from the cytochrome P4502C family

2005

Journal Article

Macrocycles and medicine - facile synthesis of a bis(macrocycle) with pendent functionality

Bernhardt, Paul V., Kim, Jee Young, Kim, Yang, Lee, Young Hoon and Chow, Sujandi (2005). Macrocycles and medicine - facile synthesis of a bis(macrocycle) with pendent functionality. Comptes Rendus Chimie, 8 (2), 211-214. doi: 10.1016/j.crci.2004.10.024

Macrocycles and medicine - facile synthesis of a bis(macrocycle) with pendent functionality

Current funding

  • 2024 - 2027
    Emergent organocopper complexes as robust catalysts for electrosynthesis
    ARC Discovery Projects
    Open grant
  • 2023 - 2026
    An Innovative, Non-Hormonal, Pharmacological Strategy that Down-Regulates the Oestrogen, Androgen, Progesterone, and Prolactin Receptors and Inhibits the Triad-of-Death in Breast Cancer (Griffith led)
    Griffith University
    Open grant
  • 2023 - 2025
    Pharmaceutical Development of Innovative "Trojan Horse" Anti-Cancer Agents that Inhibit Desmoplasia by Reprogramming Signalling (NHMRC Ideas Grant administered by Griffith University)
    Griffith University
    Open grant
  • 2022 - 2025
    Bioelectrochemical interconversion of the building blocks of life
    ARC Discovery Projects
    Open grant

Past funding

  • 2023 - 2024
    High-Resolution Electron Paramagnetic Resonance Imaging and Spectroscopy
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2021 - 2024
    Pioneering stable copper carbanions for new C-C bond forming paradigms
    ARC Discovery Projects
    Open grant
  • 2019 - 2022
    Molybdenum enzyme electrochemical communication
    ARC Discovery Projects
    Open grant
  • 2018 - 2021
    To Biochemically Trick P-Glycoprotein (Pgp) to Target Resistance via Lysosomal Pgp (NHMRC Project Grant led by Griffith University)
    Griffith University
    Open grant
  • 2017
    Advanced X-ray Facility for Structural Elucidation and Photocrystallography
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2015 - 2017
    Enzyme Electrochemical Communication
    ARC Discovery Projects
    Open grant
  • 2015 - 2019
    The fate of copper in atom transfer radical reactions
    ARC Discovery Projects
    Open grant
  • 2013 - 2014
    A facility for ex-vivo molecular imaging
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2012
    Facilities for Integrated Bioinorganic and Materials Chemistry Research
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2014
    Short circuiting redox enzymes
    ARC Discovery Projects
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2012
    Spotlighting Biologically Active Fe Chelators within Cells
    ARC Discovery Projects
    Open grant
  • 2009 - 2011
    Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class (NHMRC project grant administered by the University of Sydney)
    University of Sydney
    Open grant
  • 2008 - 2010
    Electrochemically Driven Molybdoenzyme Catalysis
    ARC Discovery Projects
    Open grant
  • 2007 - 2008
    An X-Ray Diffraction Facility for Molecular Structure Determination
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2007 - 2009
    Chemical and Biochemical Characterisation of Novel Iron Chelators with Therapeutic Potential
    ARC Discovery Projects
    Open grant
  • 2007 - 2009
    Examination of the molecular pharmacology of anthracyclines induced via their interaction with iron
    University of Sydney
    Open grant
  • 2007 - 2008
    Mechanistic Studies on Biologically Active Iron Chelators
    ARC Linkage International
    Open grant
  • 2005
    New synthetic routes to the immobilisation of mixed valence transition metal complexes on conducting metal oxides
    ARC Linkage International
    Open grant
  • 2004
    Australian Bio-Metals Research Network
    ARC Seed Funding for Research Networks
    Open grant
  • 2004 - 2006
    Chemical and Biochemical Characterisation of Novel Iron Chelators with Therapeutic Potential
    ARC Discovery Projects
    Open grant
  • 2003 - 2004
    Research expenses for visiting Research Fellow (Dr A. Meacham)
    The Royal Society
    Open grant
  • 2003 - 2005
    Mechanistic Studies of Dimethylsulfide Dehydrogenase: A Novel Bacterial Molybdoenzyme
    ARC Discovery Projects
    Open grant
  • 2003
    Novel Molecular Electrochronic Devices
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002
    Single electron reactions of multi-redox centred systems (CREDITS ONLY AWARDED)
    Australian Institute of Nuclear Science and Engineering
    Open grant
  • 2001
    Single electron transfer reactions of multi-redox centre complexes
    Australian Institute of Nuclear Science and Engineering
    Open grant
  • 2000
    Excited state dynamics of light induced molecular processes.
    ARC Australian Research Council (Small grants)
    Open grant
  • 2000 - 2002
    Mixed-Valence Transition Metal Assemblies
    ARC Australian Research Council (Large grants)
    Open grant
  • 2000
    Single electron transfer reactions of multi redox centre complexes
    Australian Institute of Nuclear Science and Engineering
    Open grant
  • 1999
    Self-assembling transition metal arrays
    UQ External Support Enabling Grant
    Open grant
  • 1999
    Single electron transfer reactions of multi redox centre complexes
    Australian Institute of Nuclear Science and Engineering
    Open grant
  • 1999
    Toward discrete dinuclear cyano-bridged coordination compounds
    ARC Australian Research Council (Small grants)
    Open grant
  • 1998
    Macrocyclic receptors for ionic guests
    ARC Australian Research Council (Small grants)
    Open grant
  • 1998
    Toward supramolecular charge separated molecules
    ARC Australian Research Council (Small grants)
    Open grant
  • 1997 - 1998
    Single electron transfer reactions of multi-redox centre complexes
    Australian Institute of Nuclear Science and Engineering
    Open grant
  • 1997
    Toward Proactive Supramolecular Coordination Compounds
    UQ External Support Enabling Grant
    Open grant
  • 1996
    Single electron transfer reactions of multi-redox centre complexes
    Australian Institute of Nuclear Science and Engineering
    Open grant
  • 1996
    Structurally organised oligonuclear coordination compounds
    University of Queensland New Staff Research Grant
    Open grant

Availability

Professor Paul Bernhardt is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Quantum Chemistry as a tool for Spectroscopic Analysis

    Principal Advisor

  • Doctor Philosophy

    Quantum Chemistry as a tool for Spectroscopic Analysis

    Principal Advisor

  • Doctor Philosophy

    Developing novel copper catalysts for carbon-carbon bond forming reactions using electrosynthesis.

    Principal Advisor

    Other advisors: Professor Craig Williams, Dr Masnun Naher

  • Doctor Philosophy

    Electrochemical investigations of bacterial molybdenum enzymes

    Associate Advisor

    Other advisors: Professor Ulrike Kappler

  • Doctor Philosophy

    Development of innovative synthetic methodologies: electrochemical Atom Transfer Radical Addition (eATRA) and strained nitrogen ring synthesis paradigms

    Associate Advisor

    Other advisors: Professor Craig Williams

  • Doctor Philosophy

    New Applications for Photoactive Lanthanoid and Earth Abundant Metal Complexes

    Associate Advisor

    Other advisors: Associate Professor Evan Moore

  • Doctor Philosophy

    New Applications for Photoactive Lanthanoid and Earth Abundant Metal Complexes

    Associate Advisor

    Other advisors: Associate Professor Evan Moore

  • Doctor Philosophy

    Pioneering stable copper carbanions for new C-C bond forming paradigms

    Associate Advisor

    Other advisors: Professor Craig Williams

Completed supervision

Enquiries

Contact Professor Paul Bernhardt directly for media enquiries about:

  • Crystallography
  • Electrochemistry
  • Transition metal chemistry

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