Professor Paul Bernhardt
Professor

Paul Bernhardt

Email: 
Phone: 
+61 7 336 54266

Background

After completing my undergraduate and postgraduate studies at the University of Newcastle, I held a Postdoctoral Fellowship at the University of Basel (Switzerland) from 1990-2. I returned to Australia in 1993 to take up an Australian Research Council Postdoctoral Fellowship at the Australian National University (Canberra) from 1993-4. I joined The University of Queensland in 1994.

Availability

Professor Paul Bernhardt is:
Available for supervision
Media expert

Fields of research

Inorganic chemistry Medicinal and biomolecular chemistry

Qualifications

  • Doctor of Philosophy, University of Newcastle

Research interests

  • Protein Electrochemistry

    This research involves incorporating redox active enzymes with electrochemical systems such that the enzyme functions natively whilst in communication with an electrode (rather than with a natural electron transfer partner). We are currently investigating a number of systems, most from the molybdenum enzyme family that catalyse oxygen transfer reactions of both organic and inorganic substrates.

  • Copper Complexes as Atom Transfer Radical Catalysts

    Atom transfer radical polymerisation (ATRP) is one of the most widely used 'controlled' radical polymerisation techniques and has resulted in polymers with well defined molecular weights and architectures. Our work is focused on complexes that catalyse this process by generating organic radicals from the simple reaction between a Cu(I) complex and an alkyl halide initiator. We can probe this atom transfer reaction with cyclic voltammetry and we have gained new insight to this interesting and fundamentally important reaction. This has now progressed to developing electrocatalytic synthetic methods for C-C bond formation reactions in collaboration with Prof. Craig Williams (SCMB).

Research impacts

My research interests include all aspects of coordination chemistry; particularly its relevance to the areas of electrochemistry, bioinorganic chemistry, spectroscopy and catalysis.

In recent years some of the areas in which we have been, and continue to be, actively involved include:

  • Enzyme electrochemistry (collaborations with several UQ and international groups).
  • Invesitigation of copper complexes that are active in atom transfer radical polymerisation catalysis
  • Transition metal-mediated organic oxidation and reduction reactions

Search Professor Paul Bernhardt’s works on UQ eSpace

552 works between 1987 and 2025
All (552) Journal Article (519) Book Chapter (3) Conference Publication (29) Other Outputs (1)

501 - 520 of 552 works

1997

Journal Article

Macrocycle formation through carbon acid-formaldehyde condensation reactions of bis(propane-1,2-diamine)-and bis(2-methylpropane-1,2-diamine)-copper(II) ions

Rossignoli, Monica, Bernhardt, Paul V., Lawrance, Geoffrey A. and Maeder, Marcel (1997). Macrocycle formation through carbon acid-formaldehyde condensation reactions of bis(propane-1,2-diamine)-and bis(2-methylpropane-1,2-diamine)-copper(II) ions. Australian Journal of Chemistry, 50 (6), 527-534.

Macrocycle formation through carbon acid-formaldehyde condensation reactions of bis(propane-1,2-diamine)-and bis(2-methylpropane-1,2-diamine)-copper(II) ions

1997

Journal Article

Structural and electron self-exchange rate variations in isomeric (hexaamine)cobalt(III/II) complexes

Bernhardt, PV, Jones, LA and Sharpe, PC (1997). Structural and electron self-exchange rate variations in isomeric (hexaamine)cobalt(III/II) complexes. Inorganic Chemistry, 36 (11), 2420-2425. doi: 10.1021/ic961345e

Structural and electron self-exchange rate variations in isomeric (hexaamine)cobalt(III/II) complexes

1997

Journal Article

Macrocycle formation through carbon acid-formaldehyde condensation reactions of bis(propane-1,2-diamine)- and bis (2-methylpropane-1,2-diamine)-copper(II) ions

Rossignoli, M, Bernhardt, PV, Lawrance, GA and Maeder, M (1997). Macrocycle formation through carbon acid-formaldehyde condensation reactions of bis(propane-1,2-diamine)- and bis (2-methylpropane-1,2-diamine)-copper(II) ions. Australian Journal of Chemistry, 50 (6), 529-534. doi: 10.1071/C96219

Macrocycle formation through carbon acid-formaldehyde condensation reactions of bis(propane-1,2-diamine)- and bis (2-methylpropane-1,2-diamine)-copper(II) ions

1997

Journal Article

Self-assembly of a tetranuclear macrocyclic copper(II) complex

Bernhardt, PV and Jones, LA (1997). Self-assembly of a tetranuclear macrocyclic copper(II) complex. Chemical Communications (7), 655-656. doi: 10.1039/a700213k

Self-assembly of a tetranuclear macrocyclic copper(II) complex

1997

Journal Article

On the structure, electrochemistry, and spectroscopy of the (N,N'-bis(2'-(dimethylamino)ethyl)-N,N'-dimethylpropane-1,3-diamine)copper(II) ion

Bernhardt, PV (1997). On the structure, electrochemistry, and spectroscopy of the (N,N'-bis(2'-(dimethylamino)ethyl)-N,N'-dimethylpropane-1,3-diamine)copper(II) ion. Journal of The American Chemical Society, 119 (4), 771-774. doi: 10.1021/ja961764a

On the structure, electrochemistry, and spectroscopy of the (N,N'-bis(2'-(dimethylamino)ethyl)-N,N'-dimethylpropane-1,3-diamine)copper(II) ion

1997

Journal Article

Nitrogen- and carbon-based isomerism in the copper(II) complexes of 6,13-dimethyl-1,4,8,11-tetraazacyclotetradecane-6,13-diamine

Bernhardt, PV, Jones, LA and Sharpe, PC (1997). Nitrogen- and carbon-based isomerism in the copper(II) complexes of 6,13-dimethyl-1,4,8,11-tetraazacyclotetradecane-6,13-diamine. Journal of The Chemical Society-dalton Transactions (7), 1169-1175. doi: 10.1039/a606476k

Nitrogen- and carbon-based isomerism in the copper(II) complexes of 6,13-dimethyl-1,4,8,11-tetraazacyclotetradecane-6,13-diamine

1997

Journal Article

Molybdenum carbonyl complexes of pendant-arm polyazamacrocycles

Rossignoli, M, Bernhardt, PV and Lawrance, GA (1997). Molybdenum carbonyl complexes of pendant-arm polyazamacrocycles. Journal of The Chemical Society-dalton Transactions (22), 4247-4250. doi: 10.1039/a704343k

Molybdenum carbonyl complexes of pendant-arm polyazamacrocycles

1997

Journal Article

Gold(III) template synthesis of a pendant-arm macrocycle

Rossignoli, M, Bernhardt, PV, Lawrance, GA and Maeder, M (1997). Gold(III) template synthesis of a pendant-arm macrocycle. Journal of The Chemical Society-dalton Transactions (3), 323-327. doi: 10.1039/a606678j

Gold(III) template synthesis of a pendant-arm macrocycle

1996

Journal Article

The potentially hexadentate isomeric macrocycles trans- and cis-6,13-diethyl-1,4,8,11-tetraazacyclotetradecane-6,13-diamine and their cobalt(III) complexes: Unexpected conformational behavior

Bernhardt, P.V., Byriel, K.A., Kennard, C.H.L. and Sharpe, P.C. (1996). The potentially hexadentate isomeric macrocycles trans- and cis-6,13-diethyl-1,4,8,11-tetraazacyclotetradecane-6,13-diamine and their cobalt(III) complexes: Unexpected conformational behavior. Inorganic Chemistry, 35 (7), 2045-2052. doi: 10.1021/ic951260y

The potentially hexadentate isomeric macrocycles trans- and cis-6,13-diethyl-1,4,8,11-tetraazacyclotetradecane-6,13-diamine and their cobalt(III) complexes: Unexpected conformational behavior

1996

Journal Article

Stereoselective assembly of a new pendant-arm macrocycle

Bernhardt, Paul V., Byriel, Karl A., Kennard, Colin H. L. and Sharpe, Philip C. (1996). Stereoselective assembly of a new pendant-arm macrocycle. Journal of the Chemical Society - Dalton Transactions (1), 145-146. doi: 10.1039/dt9960000145

Stereoselective assembly of a new pendant-arm macrocycle

1996

Journal Article

Unexpected rearrangement of a novel pendent-arm tetraazamacrocyclic complex

Bernhardt P.V. and Sharpe P.C. (1996). Unexpected rearrangement of a novel pendent-arm tetraazamacrocyclic complex. Chemical Communications (11), 1267-1268. doi: 10.1039/cc9960001267

Unexpected rearrangement of a novel pendent-arm tetraazamacrocyclic complex

1996

Journal Article

N-methylation of diamino-substituted macrocyclic complexes: Intermolecular reactions

Bernhardt, PV (1996). N-methylation of diamino-substituted macrocyclic complexes: Intermolecular reactions. Journal of The Chemical Society-dalton Transactions (23), 4319-4324. doi: 10.1039/dt9960004319

N-methylation of diamino-substituted macrocyclic complexes: Intermolecular reactions

1996

Journal Article

N-methylation of diamino-substituted macrocyclic complexes: Intramolecular cyclisation

Bernhardt, PV, Hetherington, JC and Jones, LA (1996). N-methylation of diamino-substituted macrocyclic complexes: Intramolecular cyclisation. Journal of The Chemical Society-dalton Transactions (23), 4325-4330. doi: 10.1039/dt9960004325

N-methylation of diamino-substituted macrocyclic complexes: Intramolecular cyclisation

1995

Journal Article

COPPER(II) COMPLEXES OF SUBSTITUTED MACROBICYCLIC HEXAAMINES - COMBINED TRIGONAL AND TETRAGONAL DISTORTIONS

BERNHARDT, PV, BRAMLEY, R, ENGELHARDT, LM, HARROWFIELD, JM, HOCKLESS, DCR, KORYBUTDASZKIEWICZ, BR, KRAUSZ, ER, MORGAN, T, SARGESON, AM, SKELTON, BW and WHITE, AH (1995). COPPER(II) COMPLEXES OF SUBSTITUTED MACROBICYCLIC HEXAAMINES - COMBINED TRIGONAL AND TETRAGONAL DISTORTIONS. Inorganic Chemistry, 34 (14), 3589-3599. doi: 10.1021/ic00118a005

COPPER(II) COMPLEXES OF SUBSTITUTED MACROBICYCLIC HEXAAMINES - COMBINED TRIGONAL AND TETRAGONAL DISTORTIONS

1994

Journal Article

N-METHYLATED MACROBICYCLIC HEXAAMINES OF COPPER(II) AND NICKEL(II) - LARGE STERIC EFFECTS

BERNHARDT, PV, HARROWFIELD, JM, HOCKLESS, DCR and SARGESON, AM (1994). N-METHYLATED MACROBICYCLIC HEXAAMINES OF COPPER(II) AND NICKEL(II) - LARGE STERIC EFFECTS. Inorganic Chemistry, 33 (25), 5659-5670. doi: 10.1021/ic00103a011

N-METHYLATED MACROBICYCLIC HEXAAMINES OF COPPER(II) AND NICKEL(II) - LARGE STERIC EFFECTS

1994

Journal Article

STABILIZATION OF COBALT CAGE CONFORMERS IN THE SOLID-STATE AND SOLUTION

BERNHARDT, PV, BYGOTT, AMT, GEUE, RJ, HENDRY, AJ, KORYBUTDASZKIEWICZ, BR, LAY, PA, PLADZIEWICZ, , SARGESON, AM and WILLIS, AC (1994). STABILIZATION OF COBALT CAGE CONFORMERS IN THE SOLID-STATE AND SOLUTION. Inorganic Chemistry, 33 (20), 4553-4561. doi: 10.1021/ic00098a023

STABILIZATION OF COBALT CAGE CONFORMERS IN THE SOLID-STATE AND SOLUTION

1994

Journal Article

METAL-DIRECTED SYNTHESIS OF MACROCYCLIC TETRAAMINES WITH PENDANT NITRO OR AMINE GROUPS, BASED ON TRANS-CYCLOHEXANE-1,2-DIAMINE

BERNHARDT, PV, COMBA, P, ELLIOTT, BL, LAWRANCE, GA, MAEDER, M, OLEARY, MA, WEI, G and WILKES, EN (1994). METAL-DIRECTED SYNTHESIS OF MACROCYCLIC TETRAAMINES WITH PENDANT NITRO OR AMINE GROUPS, BASED ON TRANS-CYCLOHEXANE-1,2-DIAMINE. Australian Journal of Chemistry, 47 (6), 1171-1178. doi: 10.1071/CH9941171

METAL-DIRECTED SYNTHESIS OF MACROCYCLIC TETRAAMINES WITH PENDANT NITRO OR AMINE GROUPS, BASED ON TRANS-CYCLOHEXANE-1,2-DIAMINE

1994

Journal Article

QUINQUEDENTATE COORDINATION OF 3-[(2'-AMINO-ETHYL)AMINO]-2-[(2''-AMINOETHYL)AMINOMETHYL]PROPIONIC ACID (LH) - CRYSTAL-STRUCTURE OF TRANS-[CO(L)CL][CLO4].H2O AND MOLECULAR MECHANICS EXAMINATION OF ISOMERS

BERNHARDT, PV, HAMBLEY, TW, LAWRANCE, GA and MOLLOY, KJ (1994). QUINQUEDENTATE COORDINATION OF 3-[(2'-AMINO-ETHYL)AMINO]-2-[(2''-AMINOETHYL)AMINOMETHYL]PROPIONIC ACID (LH) - CRYSTAL-STRUCTURE OF TRANS-[CO(L)CL][CLO4].H2O AND MOLECULAR MECHANICS EXAMINATION OF ISOMERS. Australian Journal of Chemistry, 47 (5), 817-827. doi: 10.1071/CH9940817

QUINQUEDENTATE COORDINATION OF 3-[(2'-AMINO-ETHYL)AMINO]-2-[(2''-AMINOETHYL)AMINOMETHYL]PROPIONIC ACID (LH) - CRYSTAL-STRUCTURE OF TRANS-[CO(L)CL][CLO4].H2O AND MOLECULAR MECHANICS EXAMINATION OF ISOMERS

1993

Journal Article

RESOLUTION OF RACEMIC AMINO-ACIDS VIA STEREOSELECTIVE LIGAND-EXCHANGE REACTIONS ON AN OPTICALLY PURE NICKEL(II) COMPLEX

BERNHARDT, PV, COMBA, P, HAMBLEY, TW, SOVAGO, and VARNAGY, K (1993). RESOLUTION OF RACEMIC AMINO-ACIDS VIA STEREOSELECTIVE LIGAND-EXCHANGE REACTIONS ON AN OPTICALLY PURE NICKEL(II) COMPLEX. Journal of the Chemical Society-Dalton Transactions (13), 2023-2026. doi: 10.1039/dt9930002023

RESOLUTION OF RACEMIC AMINO-ACIDS VIA STEREOSELECTIVE LIGAND-EXCHANGE REACTIONS ON AN OPTICALLY PURE NICKEL(II) COMPLEX

1993

Journal Article

PREDICTION AND INTERPRETATION OF ELECTRONIC-SPECTRA OF TRANSITION-METAL COMPLEXES VIA THE COMBINATION OF MOLECULAR MECHANICS AND ANGULAR OVERLAP MODEL-CALCULATIONS

BERNHARDT, PV and COMBA, P (1993). PREDICTION AND INTERPRETATION OF ELECTRONIC-SPECTRA OF TRANSITION-METAL COMPLEXES VIA THE COMBINATION OF MOLECULAR MECHANICS AND ANGULAR OVERLAP MODEL-CALCULATIONS. Inorganic Chemistry, 32 (13), 2798-2803. doi: 10.1021/ic00065a003

PREDICTION AND INTERPRETATION OF ELECTRONIC-SPECTRA OF TRANSITION-METAL COMPLEXES VIA THE COMBINATION OF MOLECULAR MECHANICS AND ANGULAR OVERLAP MODEL-CALCULATIONS

Current funding

  • 2024 - 2027
    Emergent organocopper complexes as robust catalysts for electrosynthesis
    ARC Discovery Projects
    Open grant
  • 2023 - 2026
    An Innovative, Non-Hormonal, Pharmacological Strategy that Down-Regulates the Oestrogen, Androgen, Progesterone, and Prolactin Receptors and Inhibits the Triad-of-Death in Breast Cancer (Griffith led)
    Griffith University
    Open grant
  • 2023 - 2025
    Pharmaceutical Development of Innovative "Trojan Horse" Anti-Cancer Agents that Inhibit Desmoplasia by Reprogramming Signalling (NHMRC Ideas Grant administered by Griffith University)
    Griffith University
    Open grant

Past funding

  • 2023 - 2024
    High-Resolution Electron Paramagnetic Resonance Imaging and Spectroscopy
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2022 - 2025
    Bioelectrochemical interconversion of the building blocks of life
    ARC Discovery Projects
    Open grant
  • 2021 - 2024
    Pioneering stable copper carbanions for new C-C bond forming paradigms
    ARC Discovery Projects
    Open grant
  • 2019 - 2022
    Molybdenum enzyme electrochemical communication
    ARC Discovery Projects
    Open grant
  • 2018 - 2021
    To Biochemically Trick P-Glycoprotein (Pgp) to Target Resistance via Lysosomal Pgp (NHMRC Project Grant led by Griffith University)
    Griffith University
    Open grant
  • 2017
    Advanced X-ray Facility for Structural Elucidation and Photocrystallography
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2015 - 2017
    Enzyme Electrochemical Communication
    ARC Discovery Projects
    Open grant
  • 2015 - 2019
    The fate of copper in atom transfer radical reactions
    ARC Discovery Projects
    Open grant
  • 2013 - 2014
    A facility for ex-vivo molecular imaging
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2012
    Facilities for Integrated Bioinorganic and Materials Chemistry Research
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2014
    Short circuiting redox enzymes
    ARC Discovery Projects
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2012
    Spotlighting Biologically Active Fe Chelators within Cells
    ARC Discovery Projects
    Open grant
  • 2009 - 2011
    Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class (NHMRC project grant administered by the University of Sydney)
    University of Sydney
    Open grant
  • 2008 - 2010
    Electrochemically Driven Molybdoenzyme Catalysis
    ARC Discovery Projects
    Open grant
  • 2007 - 2008
    An X-Ray Diffraction Facility for Molecular Structure Determination
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2007 - 2009
    Chemical and Biochemical Characterisation of Novel Iron Chelators with Therapeutic Potential
    ARC Discovery Projects
    Open grant
  • 2007 - 2009
    Examination of the molecular pharmacology of anthracyclines induced via their interaction with iron
    University of Sydney
    Open grant
  • 2007 - 2008
    Mechanistic Studies on Biologically Active Iron Chelators
    ARC Linkage International
    Open grant
  • 2005
    New synthetic routes to the immobilisation of mixed valence transition metal complexes on conducting metal oxides
    ARC Linkage International
    Open grant
  • 2004
    Australian Bio-Metals Research Network
    ARC Seed Funding for Research Networks
    Open grant
  • 2004 - 2006
    Chemical and Biochemical Characterisation of Novel Iron Chelators with Therapeutic Potential
    ARC Discovery Projects
    Open grant
  • 2003 - 2004
    Research expenses for visiting Research Fellow (Dr A. Meacham)
    The Royal Society
    Open grant
  • 2003 - 2005
    Mechanistic Studies of Dimethylsulfide Dehydrogenase: A Novel Bacterial Molybdoenzyme
    ARC Discovery Projects
    Open grant
  • 2003
    Novel Molecular Electrochronic Devices
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002
    Single electron reactions of multi-redox centred systems (CREDITS ONLY AWARDED)
    Australian Institute of Nuclear Science and Engineering
    Open grant
  • 2001
    Single electron transfer reactions of multi-redox centre complexes
    Australian Institute of Nuclear Science and Engineering
    Open grant
  • 2000
    Excited state dynamics of light induced molecular processes.
    ARC Australian Research Council (Small grants)
    Open grant
  • 2000 - 2002
    Mixed-Valence Transition Metal Assemblies
    ARC Australian Research Council (Large grants)
    Open grant
  • 2000
    Single electron transfer reactions of multi redox centre complexes
    Australian Institute of Nuclear Science and Engineering
    Open grant
  • 1999
    Self-assembling transition metal arrays
    UQ External Support Enabling Grant
    Open grant
  • 1999
    Single electron transfer reactions of multi redox centre complexes
    Australian Institute of Nuclear Science and Engineering
    Open grant
  • 1999
    Toward discrete dinuclear cyano-bridged coordination compounds
    ARC Australian Research Council (Small grants)
    Open grant
  • 1998
    Macrocyclic receptors for ionic guests
    ARC Australian Research Council (Small grants)
    Open grant
  • 1998
    Toward supramolecular charge separated molecules
    ARC Australian Research Council (Small grants)
    Open grant
  • 1997 - 1998
    Single electron transfer reactions of multi-redox centre complexes
    Australian Institute of Nuclear Science and Engineering
    Open grant
  • 1997
    Toward Proactive Supramolecular Coordination Compounds
    UQ External Support Enabling Grant
    Open grant
  • 1996
    Single electron transfer reactions of multi-redox centre complexes
    Australian Institute of Nuclear Science and Engineering
    Open grant
  • 1996
    Structurally organised oligonuclear coordination compounds
    University of Queensland New Staff Research Grant
    Open grant

Availability

Professor Paul Bernhardt is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Developing novel copper catalysts for carbon-carbon bond forming reactions using electrosynthesis.

    Principal Advisor

    Other advisors: Professor Craig Williams, Dr Masnun Naher

  • Doctor Philosophy

    New Applications for Photoactive Lanthanoid and Earth Abundant Metal Complexes

    Associate Advisor

    Other advisors: Associate Professor Evan Moore

  • Doctor Philosophy

    Mass-Transfer Control-Enabled Electrochemical Reactions

    Associate Advisor

    Other advisors: Dr David Cantillo

  • Doctor Philosophy

    Electrochemical investigations of bacterial molybdenum enzymes

    Associate Advisor

    Other advisors: Professor Ulrike Kappler

Completed supervision

Enquiries

Contact Professor Paul Bernhardt directly for media enquiries about:

  • Crystallography
  • Electrochemistry
  • Transition metal chemistry

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