
Overview
Background
Professor Ian Frazer is a clinician scientist, trained as a clinical immunologist in Scotland. As a professor at the University of Queensland, he leads a research group working at TRI in Brisbane, Australia on the immunobiology of epithelial cancers. He is recognised as co-inventor of the technology enabling the HPV vaccines, currently used worldwide to help prevent cervical cancer. He heads a biotechnology company, Jingang Medicine (Aus) Pty Ltd, working on new vaccine technologies, and is a board member of several companies and not for profit organisations. He was the inaugural president of the Australian Academy of Health and Medical Sciences, and a member of the Australian National Science and Technology Council. He chairs the Australian Medical Research Advisory Board of the Medical Research Future Fund.
He was recognised as Australian of the Year in 2006. He was recipient of the Prime Ministers Prize for Science, and of the Balzan Prize, in 2008, and was elected Fellow of the Royal Society of London in 2012. He was appointed Companion of the Order of Australia in the Queen’s Birthday Honours list in 2013.
Availability
- Professor Ian Frazer is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), University of Edinburgh
- Bachelor of Medicine Surgery, University of Edinburgh
- Doctoral Diploma of Medicine, University of Melbourne
- Royal College of Pathologists of Australasia, Royal College of Pathologists of Australasia
- Royal College of Physicians of Edinburgh, Royal College of Physicians of Edinburgh
Works
Search Professor Ian Frazer’s works on UQ eSpace
2006
Journal Article
Prophylactic HPV vaccines: Underlying mechanisms
Stanley, Margaret, Lowy, Douglas R. and Frazer, Ian (2006). Prophylactic HPV vaccines: Underlying mechanisms. Vaccine, 24 (Supplement 3: HPV Vaccines and Screening in the Prevention of Cervical Cancer), S106-S113. doi: 10.1016/j.vaccine.2006.05.110
2006
Journal Article
Finding a vaccine for human papillomavirus
Frazer, Ian H. and Cox, John (2006). Finding a vaccine for human papillomavirus. The Lancet, 367 (9528), 2058-2059. doi: 10.1016/S0140-6736(06)68921-6
2006
Conference Publication
Advances in prevention of cervical cancer and other human papillomavirus-related diseases
Frazer, Ian H., Cox, J. Thomas, Mayeaux Jr., Edward John, Franco, Eduardo L., Moscicki, Anna-Barbara, Palefsky, Joel M., Ferris, Daron G., Ferenczy, Alex S. and Villa, Luisa L. (2006). Advances in prevention of cervical cancer and other human papillomavirus-related diseases. doi: 10.1097/01.inf.0000196485.86376.46
2006
Journal Article
Advances in prevention of cervical cancer and other human papillomavirus-related diseases
Frazer, Ian H., Cox, J. Thomas, Mayeaux, Edward John, Franco, Eduardo L., Moscicki, Anna-Barbara, Palefsky, Joel M., Ferris, Daron G., Ferenczy, Alex S. and Villa, Luisa L. (2006). Advances in prevention of cervical cancer and other human papillomavirus-related diseases. Pediatric Infectious Disease Journal, 25 (Supp. 2), S65-S81. doi: 10.1097/01.inf.0000196485.86376.46
2006
Journal Article
Harnessing the immune system to prevent cervical cancer
Frazer, I. H. (2006). Harnessing the immune system to prevent cervical cancer. Cancer Forum, 30 (2), 115-117.
2006
Journal Article
Serologic response to human papillomavirus 16 among Australian women with high-grade cervical intraepithelial neoplasia
Tabrizi, SN, Frazer, IH and Garland, SM (2006). Serologic response to human papillomavirus 16 among Australian women with high-grade cervical intraepithelial neoplasia. International Journal of Gynecological Cancer, 16 (3), 1032-1035. doi: 10.1111/j.1525-1438.2006.00587.x
2006
Journal Article
IL10 and IL12B polymorphisms each influence IL-12p70 secretion by dendritic cells in response to LPS
Peng, J. C., Abu Bakar, S., Richardson, M. M., Jonsson, J. J., Frazer, I. H., Nielsen, L. K., Morahan, G. and Thomas, R. (2006). IL10 and IL12B polymorphisms each influence IL-12p70 secretion by dendritic cells in response to LPS. Immunology And Cell Biology, 84 (2), 227-232. doi: 10.1111/j.1440-1711.2006.01419.x
2006
Journal Article
Progress in cancer control: the Alan Coates effect
Frazer, I. H. and Kefford, R. F. (2006). Progress in cancer control: the Alan Coates effect. Cancer Forum, 30 (2), 96-97.
2006
Journal Article
God's gift to women: The human papillomavirus vaccine
Frazer, I. (2006). God's gift to women: The human papillomavirus vaccine. Immunity, 25 (2), 179-184. doi: 10.1016/j.immuni.2006.08.002
2005
Journal Article
The role of CD4 T help in multiple vaccinations when using minimal CD8 T cell epitope peptides
Khammanivong, V., Peters, T., Andrews, M., Leggatt, G. R., Frazer, I. H. and Fernando, G. J. (2005). The role of CD4 T help in multiple vaccinations when using minimal CD8 T cell epitope peptides. Tissue Antigens, 66 (5), 415-415.
2005
Journal Article
A model of peripheral CD8(+) T cell tolerance against skin antigen
Narayan, S., Fernando, G., Frazer, I. H. and Leggatt, G. (2005). A model of peripheral CD8(+) T cell tolerance against skin antigen. Tissue Antigens, 66 (5), 501-501. doi: 10.1111/j.1399-0039.2005.00523.x
2005
Journal Article
Transgenic expression of a viral oncoprotein exclusively in K14(+) epithelial cells results in peripheral but not central CD8 T cell tolerance
Leggatt, G. R., Saunders, N., Dahler, A., Fernando, G. J., Matsumoto, K., Narayan, S., Linedale, R., Choyce, A. and Frazer, I. H. (2005). Transgenic expression of a viral oncoprotein exclusively in K14(+) epithelial cells results in peripheral but not central CD8 T cell tolerance. Tissue Antigens, 66 (5), 475-476.
2005
Journal Article
Local inflammation is crucial for T cell mediated rejection of skin graft expressing foreign antigen
Zhong, J., De Kluyver, R., Leggatt, G. R., Fernando, G. J. and Frazer, I. H. (2005). Local inflammation is crucial for T cell mediated rejection of skin graft expressing foreign antigen. Tissue Antigens, 66 (5), 600-600.
2005
Journal Article
Interferon-gamma is required for killing keratinocytes in vitro and in vivo
De Kluyver, R. L., Morritz, L., Leggatt, G. R., Harris, C., Lambert, P. F. and Frazer, I. H. (2005). Interferon-gamma is required for killing keratinocytes in vitro and in vivo. Tissue Antigens, 66 (5), 394-394.
2005
Journal Article
Apoptosis mediated by CD8+T cells targeted to endogenous antigens in transgenic keratinocytes
Zhou, F., Leggatt, G., Zhong, J., Zhao, K., De Kluyver, R. and Frazer, I. H. (2005). Apoptosis mediated by CD8+T cells targeted to endogenous antigens in transgenic keratinocytes. Tissue Antigens, 66 (5), 600-600. doi: 10.1111/j.1399-0039.2005.00523.x
2005
Journal Article
Gene codon composition determines differentiation-dependent expression of a viral capsid gene in keratinocytes in vitro and in vivo
Zhao, Kong-Nan, Gu, WenYi, Fang, Ning Xia, Saunders, Nicholas A. and Frazer, Ian H. (2005). Gene codon composition determines differentiation-dependent expression of a viral capsid gene in keratinocytes in vitro and in vivo. Molecular And Cellular Biology, 25 (19), 8643-8655. doi: 10.1128/MCB.25.19.8643-8655.2005
2005
Journal Article
HPV-16 L1 VLP vaccine elicits a broad-spectrum of cytokine responses in whole blood
Pinto, Ligia A., Castle, Philip E., Roden, Richard B., Harro, Clayton D., Lowy, Douglas R., Schiller, John T., Wallace, Dora, Williams, Marcus, Kopp, William, Frazer, Ian H., Berzofsky, Jay A. and Hildesheim, Allan (2005). HPV-16 L1 VLP vaccine elicits a broad-spectrum of cytokine responses in whole blood. Vaccine, 23 (27), 3555-3564. doi: 10.1016/j.vaccine.2005.01.146
2005
Journal Article
Activation of dendritic cells by human papillomavirus-like particles through TLR4 and NF-B-mediated signalling, moderated by TGF-beta
Yan, Mengyong, Peng, Judy, Jabbar, Ibtissam A., Liu, Xiaosong, Filguueira, Luis, Frazer, Ian H. and Thomas, Ranjeny (2005). Activation of dendritic cells by human papillomavirus-like particles through TLR4 and NF-B-mediated signalling, moderated by TGF-beta. Immunology and Cell Biology, 83 (1), 83-91. doi: 10.1111/j.1440-1711.2004.01291.x
2005
Journal Article
Interferon-gamma, but not perforin or FasL, is required for killing keratinocytes in vitro and in vivo
deKluyver, R. L., Moritz, L. and Frazer, I. H. (2005). Interferon-gamma, but not perforin or FasL, is required for killing keratinocytes in vitro and in vivo. Faseb Journal, 19 (5), A1438-A1438.
2005
Other Outputs
Screening to prevent cervical cancer: Guidelines for the management of asymptomatic women with screen detected abnormalities
NHMRC Guidelines Review Group, Connelly, Luke B. and Frazer, Ian (2005). Screening to prevent cervical cancer: Guidelines for the management of asymptomatic women with screen detected abnormalities. Canberra, Australia: Commonwealth of Australia.
Funding
Current funding
Past funding
Supervision
Availability
- Professor Ian Frazer is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
The role of IL34 in HPV-mediated epithelial cancers
Principal Advisor
Other advisors: Associate Professor Graham Leggatt, Professor David Hume, Dr Janin Chandra
-
Doctor Philosophy
The Role of Bacterially Induced Inflammation in Squamous Cell Carcinoma Development
Principal Advisor
Other advisors: Professor Phil Hugenholtz, Professor Mark Morrison, Dr Debottam Sinha, Dr Janin Chandra
-
Doctor Philosophy
The role of IL34 in HPV-mediated epithelial cancers
Principal Advisor
Other advisors: Associate Professor Graham Leggatt, Professor David Hume, Dr Janin Chandra
-
Doctor Philosophy
The role of IL34 in HPV-mediated epithelial cancers
Principal Advisor
Other advisors: Associate Professor Graham Leggatt, Professor David Hume, Dr Janin Chandra
-
Doctor Philosophy
Spatial Multi-Omics Analysis of HPV-Positive Head and Neck Cancer: Tumour Oncogenesis and Discovery of Targeted Therapies
Associate Advisor
Other advisors: Dr Quan Nguyen, Associate Professor James Wells, Dr Jazmina Gonzalez Cruz
-
Doctor Philosophy
Spatial Multi-Omics Analysis of HPV-Positive Head and Neck Cancer: Tumour Oncogenesis and Discovery of Targeted Therapies
Associate Advisor
Other advisors: Dr Quan Nguyen, Associate Professor James Wells, Dr Jazmina Gonzalez Cruz
-
Doctor Philosophy
Assessment of predictors of response to checkpoint blockades in cancer patients.
Associate Advisor
Other advisors: Dr Ahmed Mehdi, Dr Janin Chandra, Dr Bree Tillett
Completed supervision
-
2024
Doctor Philosophy
The Role of Bacterially Induced Inflammation in Squamous Cell Carcinoma Development
Principal Advisor
Other advisors: Professor Phil Hugenholtz, Professor Mark Morrison, Dr Debottam Sinha, Dr Janin Chandra
-
2021
Doctor Philosophy
The role of the skin microbiota in cutaneous squamous cell carcinoma
Principal Advisor
Other advisors: Professor Mark Morrison
-
2020
Doctor Philosophy
Modulation of Immune Responses by HPV-Induced Epithelial Hyperplasia
Principal Advisor
Other advisors: Associate Professor Graham Leggatt, Dr Janin Chandra
-
2018
Doctor Philosophy
Association of Local Immune Suppression in Skin with HPV-Induced Epithelial Hyperplasia
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2017
Master Philosophy
Aetiology of Oral Cavity Squamous Cell Carcinoma - An Exploration utilising Next Generation Sequencing
Principal Advisor
-
2015
Doctor Philosophy
Mechanisms of 2,4-Dinitrochlorobenzene-induced acute inflammation in Human Papillomavirus type 16 E7 oncoprotein expressing skin
Principal Advisor
-
2014
Doctor Philosophy
Mechanisms of immunoregulation in human papillomavirus-associated epithelial hyperplasia: of mice and (wo)men
Principal Advisor
Other advisors: Professor Antje Blumenthal
-
2013
Doctor Philosophy
LANGERHANS CELLS IN SKIN EXPRESSING HUMAN PAPILLOMAVIRUS TYPE 16 E7
Principal Advisor
-
2010
Doctor Philosophy
CD4+ T cells provide help to CD8+ T cells in immune recall responses in skin
Principal Advisor
-
2010
Doctor Philosophy
Augmenting CD8+ T cell-mediated cutaneous immunotherapy in a murine model system
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2010
Doctor Philosophy
Role of dendritic epidermal T cells in skin graft rejection
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2009
Doctor Philosophy
Human Papillomavirus 16 E7 Inhibits the ability of IFN-γ in Enhancement of MHC Class I Antigen Presentation and CTL Lysis by Affecting IRF-1 Expression in Keratinocytes
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
-
2008
Doctor Philosophy
Studies on mechanisms of skin graft rejection
Principal Advisor
Other advisors: Honorary Professor Geoffrey Hill
-
2003
Doctor Philosophy
IMMUNE RESPONSE TO PAPILLOMAVIRUS INFECTION
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2002
Doctor Philosophy
DETERMINING CTL CHARACTERISTICS WHICH CORRELATE WITH TUMOUR REGRESSION IN VIVO
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2023
Doctor Philosophy
Local Delivery Of Immunotherapeutic Antibodies To Skin Cancers
Associate Advisor
Other advisors: Dr Jazmina Gonzalez Cruz, Associate Professor Graham Leggatt
-
2022
Doctor Philosophy
Understanding CD4+ T cell responses to HPV16 E7 antigen in a mouse model of precancerous skin
Associate Advisor
Other advisors: Dr Kelvin Tuong, Dr Janin Chandra
-
2021
Doctor Philosophy
The role of CD8+ T cells in the regression of squamous cell carcinoma
Associate Advisor
Other advisors: Dr Jazmina Gonzalez Cruz, Associate Professor James Wells
-
2017
Doctor Philosophy
Uncovering novel regulators of CD8+ T-cell function in the skin
Associate Advisor
Other advisors: Associate Professor James Wells
-
2016
Doctor Philosophy
Evaluating CD8+ T-cell function in skin and squamous cell carcinoma following systemic suppression with rapamycin and tacrolimus.
Associate Advisor
Other advisors: Professor Fiona Simpson, Associate Professor James Wells
-
2015
Doctor Philosophy
Characterisation of RP105's divergent functions in macrophage responses to mycobacteria and LPS
Associate Advisor
Other advisors: Professor Antje Blumenthal
-
2015
Doctor Philosophy
Contributions of Wnt signalling to immune responses during acute bacterial infection
Associate Advisor
Other advisors: Professor Antje Blumenthal
-
2011
Doctor Philosophy
The effects of the balance of Type I and Type II NKT cells on CD8 T cells and Tumour Therapy
Associate Advisor
Other advisors: Associate Professor Graham Leggatt
-
2008
Doctor Philosophy
Interactions among Control Beliefs, Illness Severity, Biological Factors and a Psychological Preparation for Heart Surgery: Predictors of Health Outcomes
Associate Advisor
Other advisors: Emeritus Professor Kenneth Pakenham
-
2007
Doctor Philosophy
Treatment of Cervical Cancer using RNA-Interference Against Human Papillomavirus Oncogenes
Associate Advisor
-
2005
Doctor Philosophy
Regulation of squamous differentiation by the E2F family transcription factors
Associate Advisor
-
2003
Doctor Philosophy
DENDRITIC CELL IMMUNOTHERAPY BASED ON HUMAN PAPILLOMAVIRUS
Associate Advisor
Other advisors: Professor Ranjeny Thomas
-
2003
Doctor Philosophy
THE ROLE OF AP2 IN SQUAMOUS DIFFERENTIATION
Associate Advisor
-
2003
Doctor Philosophy
IDENTIFICATION AND CLONING OF GENES ASSOCIATED WITH SQUAMOUS CELL CARCINOMA IN HUMAN SKIN TUMOURS
Associate Advisor
-
Doctor Philosophy
Peripheral Mechanisms of CD8+ T Cell Tolerance in H-2b K14E7 Transgenic Mice
Associate Advisor
Other advisors: Associate Professor Graham Leggatt
Media
Enquiries
Contact Professor Ian Frazer directly for media enquiries about:
- Allergy
- Autoimmune disease
- Cancer - immunity
- Cancer - vaccines to prevent
- Cervical cancer vaccine
- Education - medical
- Genital wart virus disease
- Host-virus interactions
- Immunity
- Immunodeficiency
- Immunology
- Medical education
- Papillomavirus vaccines
- Pathology
- Transplantation immunology
- Tumour immunology
- Tumour vaccines
- Vaccines
- Viral infection
- Viral vaccines
- Viruses
- Warts - genital
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