
Overview
Background
Professor Ian Frazer is a clinician scientist, trained as a clinical immunologist in Scotland. As a professor at the University of Queensland, he leads a research group working at TRI in Brisbane, Australia on the immunobiology of epithelial cancers. He is recognised as co-inventor of the technology enabling the HPV vaccines, currently used worldwide to help prevent cervical cancer. He heads a biotechnology company, Jingang Medicine (Aus) Pty Ltd, working on new vaccine technologies, and is a board member of several companies and not for profit organisations. He was the inaugural president of the Australian Academy of Health and Medical Sciences, and a member of the Australian National Science and Technology Council. He chairs the Australian Medical Research Advisory Board of the Medical Research Future Fund.
He was recognised as Australian of the Year in 2006. He was recipient of the Prime Ministers Prize for Science, and of the Balzan Prize, in 2008, and was elected Fellow of the Royal Society of London in 2012. He was appointed Companion of the Order of Australia in the Queen’s Birthday Honours list in 2013.
Availability
- Professor Ian Frazer is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), University of Edinburgh
- Bachelor of Medicine Surgery, University of Edinburgh
- Doctoral Diploma of Medicine, University of Melbourne
- Royal College of Pathologists of Australasia, Royal College of Pathologists of Australasia
- Royal College of Physicians of Edinburgh, Royal College of Physicians of Edinburgh
Works
Search Professor Ian Frazer’s works on UQ eSpace
2011
Journal Article
Increasing mechanical stimulus induces migration of Langerhans cells and impairs the immune response to intracutaneously delivered antigen
Ruutu, Merja P., Chen, Xianfeng, Joshi, Ojas, Kendall, Mark A. and Frazer, Ian H. (2011). Increasing mechanical stimulus induces migration of Langerhans cells and impairs the immune response to intracutaneously delivered antigen. Experimental Dermatology, 20 (6), 534-536. doi: 10.1111/j.1600-0625.2010.01234.x
2011
Journal Article
Prevention and treatment of papillomavirus-related cancers through immunization
Frazer, Ian H., Leggatt, Graham R. and Mattarollo, Stephen R. (2011). Prevention and treatment of papillomavirus-related cancers through immunization. Annual Review of Immunology, 29, 111-138. doi: 10.1146/annurev-immunol-031210-101308
2011
Journal Article
Human papillomavirus 16 E7 protein inhibits interferon-gamma-mediated enhancement of keratinocyte antigen processing and T-cell lysis
Zhou, Fang, Leggatt, Graham R. and Frazer, Ian H. (2011). Human papillomavirus 16 E7 protein inhibits interferon-gamma-mediated enhancement of keratinocyte antigen processing and T-cell lysis. The Federation of European Biochemical Societies (FEBS) Journal, 278 (6), 955-963. doi: 10.1111/j.1742-4658.2011.08011.x
2011
Journal Article
Regulation of immune responses to HPVinfection and during HPV-directed immunotherapy
Bhat, Purnima, Mattarollo, Stephen R., Gosmann, Christina, Frazer, Ian H. and Leggatt, Graham R. (2011). Regulation of immune responses to HPVinfection and during HPV-directed immunotherapy. Immunological Reviews, 239 (1), 85-98. doi: 10.1111/j.1600-065X.2010.00966.x
2010
Journal Article
Skin vaccination against cervical cancer associated human papillomavirus with a novel micro-projection array in a mouse model
Corbett, Holly J., Fernando, Germain J. P., Chen, Xianfeng, Frazer, Ian H. and Kendall, Mark A. F. (2010). Skin vaccination against cervical cancer associated human papillomavirus with a novel micro-projection array in a mouse model. PLoS One, 5 (10) e13460, e13460.1-e13460.9. doi: 10.1371/journal.pone.0013460
2010
Journal Article
Development of therapeutic HPV vaccines
Trimble, C. L. and Frazer, Ian H. (2010). Development of therapeutic HPV vaccines. Lancet Oncology, 10 (10), 975-980. doi: 10.1016/S1470-2045(09)70227-X
2010
Journal Article
Evaluation of a cervical cancer screening program based on HPV testing and LLETZ excision in a low resource setting
McAdam, Margaret, Sakita, Jerol, Tarivonda, Len, Pang, James and Frazer, Ian H. (2010). Evaluation of a cervical cancer screening program based on HPV testing and LLETZ excision in a low resource setting. PLoS One, 5 (10) e13266, e13266.1-e13266.6. doi: 10.1371/journal.pone.0013266
2010
Journal Article
Nanopatch-targeted skin vaccination against West Nile virus and chikungunya virus in mice
Prow, Tarl W., Chen, Xianfeng, Prow, Natalie A., Fernando, Germain J. P., Tan, Cindy S. E., Raphael, Anthony P., Chang, David, Ruutu, Merja P., Jenkins, Derek W. K., Pyke, Alyssa, Crichton, Michael L., Raphaelli, Kristin, Goh, Lucas Y. H., Frazer, Ian H., Roberts, Michael S., Gardner, Joy, Khromykh, Alexander A., Suhrbier, Andreas, Hall, Roy A. and Kendall, Mark A. F. (2010). Nanopatch-targeted skin vaccination against West Nile virus and chikungunya virus in mice. Small, 6 (16), 1776-1784. doi: 10.1002/smll.201000331
2010
Journal Article
IL-1 signalling determines the fate of skin grafts expressing non-self protein in keratinocytes
Hadis, Usriansyah, Leggatt, Graham R., Thomas, Ranjeny, Frazer, Ian H. and Kovacs, Eva M. (2010). IL-1 signalling determines the fate of skin grafts expressing non-self protein in keratinocytes. Experimental Dermatology, 19 (8), 723-729. doi: 10.1111/j.1600-0625.2010.01092.x
2010
Journal Article
Antigen-specific CD8 T cells can eliminate antigen-bearing keratinocytes with clonogenic potential via an IFN-γ-dependent mechanism
De Kluyver, Rachel L., Moritz, Linnea, Harris, Craig A., Azukizawa, Hiroaki and Frazer, Ian H. (2010). Antigen-specific CD8 T cells can eliminate antigen-bearing keratinocytes with clonogenic potential via an IFN-γ-dependent mechanism. Journal of Investigative Dermatology, 130 (7), 1841-1848. doi: 10.1038/jid.2010.49
2010
Journal Article
Measuring serum antibody to human papillomavirus following infection or vaccination
Frazer, Ian H. (2010). Measuring serum antibody to human papillomavirus following infection or vaccination. Gynecologic Oncology, 118 (1 Supplement 1), S8-S11. doi: 10.1016/j.ygyno.2010.04.003
2010
Journal Article
Antigen-specific CD4 cells assist CD8 T-effector cells in eliminating keratinocytes
Broom, Jennifer K., Lew, Andrew M., Azukizawa, Hiroaki, Kenna, Tony J., Leggatt, Graham R. and Frazer, Ian H. (2010). Antigen-specific CD4 cells assist CD8 T-effector cells in eliminating keratinocytes. Journal of Investigative Dermatology, 130 (6), 1581-1589. doi: 10.1038/jid.2010.17
2010
Journal Article
Secretion of IFN-gamma but not IL-17 by CD1d-restricted NKT cells enhances rejection of skin grafts expressing epithelial cell-derived antigen
Mattarollo, Stephen R., Yong, Michelle, Tan, Lieven, Frazer, Ian H. and Leggatt, Graham R. (2010). Secretion of IFN-gamma but not IL-17 by CD1d-restricted NKT cells enhances rejection of skin grafts expressing epithelial cell-derived antigen. Journal of Immunology, 184 (10), 5663-5669. doi: 10.4049/jimmunol.0903730
2010
Journal Article
The two faces of human papillomavirus
Frazer, Ian H. (2010). The two faces of human papillomavirus. Gynecologic Oncology, 117 (2), S4-S4. doi: 10.1016/j.ygyno.2010.01.023
2010
Journal Article
Expression of papillomavirus L1 proteins regulated by authentic gene codon usage is favoured in G2/M-like cells in differentiating keratinocytes
Ding, Jianmin, Doorbar, John, Li, Bo, Zhou, Fang, Gu, Wenyi, Zhao, Liang, Saunders, Nicholas A., Frazer, Ian H. and Zhao, Kong-Nan (2010). Expression of papillomavirus L1 proteins regulated by authentic gene codon usage is favoured in G2/M-like cells in differentiating keratinocytes. Virology, 399 (1), 46-58. doi: 10.1016/j.virol.2009.12.021
2010
Journal Article
Invariant NKT Cells in Hyperplastic Skin Induce a Local Immune Suppressive Environment by IFN-gamma Production
Mattarollo, Stephen R., Rahimpour, Azad, Choyce, Allison, Godfrey, Dale I., Leggatt, Graham R. and Frazer, Ian H. (2010). Invariant NKT Cells in Hyperplastic Skin Induce a Local Immune Suppressive Environment by IFN-gamma Production. Journal of Immunology, 184 (3), 1242-1250. doi: 10.4049/jimmunol.0902191
2010
Journal Article
Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control
Ferreira, Mar, Mangino, M, Brumme, CJ, Zhao, ZZ, Medland, SE, Wright, MJ, Nyholt, DR, Gordon, S, Campbell, M, McEvoy, BP, Henders, A, Evans, DM, Lanchbury, JS, Pereyra, F, Walker, BD, Haas, DW, Soranzo, N, Spector, TD, de Bakker, PIW, Frazer, IH, Montgomery, GW, Martin, NG and Int HIV Controllers Study (2010). Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control. American Journal of Human Genetics, 86 (1), 88-92. doi: 10.1016/j.ajhg.2009.12.008
2010
Book Chapter
Vaccines against human papillomaviruses
Jansen, Kathrin U. and Frazer, Ian H. (2010). Vaccines against human papillomaviruses. New generation vaccines. (pp. 954-961) edited by Myron M. Levine. New York, U.S.A.: Informa Healthcare.
2010
Book Chapter
Human papillomaviruses
Frazer, Ian H. (2010). Human papillomaviruses. Vaccines: a biography. (pp. 361-373) edited by Andrew W. Artenstein. New York, United States: Springer. doi: 10.1007/978-1-4419-1108-7_21
2010
Journal Article
Cervical cancer vaccine development
Frazer, Ian H. (2010). Cervical cancer vaccine development. Sexual Health, 7 (3), 230-234. doi: 10.1071/SH09132
Funding
Current funding
Past funding
Supervision
Availability
- Professor Ian Frazer is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
The role of IL34 in HPV-mediated epithelial cancers
Principal Advisor
Other advisors: Associate Professor Graham Leggatt, Professor David Hume, Dr Janin Chandra
-
Doctor Philosophy
The Role of Bacterially Induced Inflammation in Squamous Cell Carcinoma Development
Principal Advisor
Other advisors: Professor Phil Hugenholtz, Professor Mark Morrison, Dr Debottam Sinha, Dr Janin Chandra
-
Doctor Philosophy
The role of IL34 in HPV-mediated epithelial cancers
Principal Advisor
Other advisors: Associate Professor Graham Leggatt, Professor David Hume, Dr Janin Chandra
-
Doctor Philosophy
The role of IL34 in HPV-mediated epithelial cancers
Principal Advisor
Other advisors: Associate Professor Graham Leggatt, Professor David Hume, Dr Janin Chandra
-
Doctor Philosophy
Spatial Multi-Omics Analysis of HPV-Positive Head and Neck Cancer: Tumour Oncogenesis and Discovery of Targeted Therapies
Associate Advisor
Other advisors: Dr Quan Nguyen, Associate Professor James Wells, Dr Jazmina Gonzalez Cruz
-
Doctor Philosophy
Spatial Multi-Omics Analysis of HPV-Positive Head and Neck Cancer: Tumour Oncogenesis and Discovery of Targeted Therapies
Associate Advisor
Other advisors: Dr Quan Nguyen, Associate Professor James Wells, Dr Jazmina Gonzalez Cruz
-
Doctor Philosophy
Assessment of predictors of response to checkpoint blockades in cancer patients.
Associate Advisor
Other advisors: Dr Ahmed Mehdi, Dr Janin Chandra, Dr Bree Tillett
Completed supervision
-
2024
Doctor Philosophy
The Role of Bacterially Induced Inflammation in Squamous Cell Carcinoma Development
Principal Advisor
Other advisors: Professor Phil Hugenholtz, Professor Mark Morrison, Dr Debottam Sinha, Dr Janin Chandra
-
2021
Doctor Philosophy
The role of the skin microbiota in cutaneous squamous cell carcinoma
Principal Advisor
Other advisors: Professor Mark Morrison
-
2020
Doctor Philosophy
Modulation of Immune Responses by HPV-Induced Epithelial Hyperplasia
Principal Advisor
Other advisors: Associate Professor Graham Leggatt, Dr Janin Chandra
-
2018
Doctor Philosophy
Association of Local Immune Suppression in Skin with HPV-Induced Epithelial Hyperplasia
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2017
Master Philosophy
Aetiology of Oral Cavity Squamous Cell Carcinoma - An Exploration utilising Next Generation Sequencing
Principal Advisor
-
2015
Doctor Philosophy
Mechanisms of 2,4-Dinitrochlorobenzene-induced acute inflammation in Human Papillomavirus type 16 E7 oncoprotein expressing skin
Principal Advisor
-
2014
Doctor Philosophy
Mechanisms of immunoregulation in human papillomavirus-associated epithelial hyperplasia: of mice and (wo)men
Principal Advisor
Other advisors: Professor Antje Blumenthal
-
2013
Doctor Philosophy
LANGERHANS CELLS IN SKIN EXPRESSING HUMAN PAPILLOMAVIRUS TYPE 16 E7
Principal Advisor
-
2010
Doctor Philosophy
CD4+ T cells provide help to CD8+ T cells in immune recall responses in skin
Principal Advisor
-
2010
Doctor Philosophy
Augmenting CD8+ T cell-mediated cutaneous immunotherapy in a murine model system
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2010
Doctor Philosophy
Role of dendritic epidermal T cells in skin graft rejection
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2009
Doctor Philosophy
Human Papillomavirus 16 E7 Inhibits the ability of IFN-γ in Enhancement of MHC Class I Antigen Presentation and CTL Lysis by Affecting IRF-1 Expression in Keratinocytes
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
-
2008
Doctor Philosophy
Studies on mechanisms of skin graft rejection
Principal Advisor
Other advisors: Honorary Professor Geoffrey Hill
-
2003
Doctor Philosophy
IMMUNE RESPONSE TO PAPILLOMAVIRUS INFECTION
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2002
Doctor Philosophy
DETERMINING CTL CHARACTERISTICS WHICH CORRELATE WITH TUMOUR REGRESSION IN VIVO
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2023
Doctor Philosophy
Local Delivery Of Immunotherapeutic Antibodies To Skin Cancers
Associate Advisor
Other advisors: Dr Jazmina Gonzalez Cruz, Associate Professor Graham Leggatt
-
2022
Doctor Philosophy
Understanding CD4+ T cell responses to HPV16 E7 antigen in a mouse model of precancerous skin
Associate Advisor
Other advisors: Dr Kelvin Tuong, Dr Janin Chandra
-
2021
Doctor Philosophy
The role of CD8+ T cells in the regression of squamous cell carcinoma
Associate Advisor
Other advisors: Dr Jazmina Gonzalez Cruz, Associate Professor James Wells
-
2017
Doctor Philosophy
Uncovering novel regulators of CD8+ T-cell function in the skin
Associate Advisor
Other advisors: Associate Professor James Wells
-
2016
Doctor Philosophy
Evaluating CD8+ T-cell function in skin and squamous cell carcinoma following systemic suppression with rapamycin and tacrolimus.
Associate Advisor
Other advisors: Professor Fiona Simpson, Associate Professor James Wells
-
2015
Doctor Philosophy
Characterisation of RP105's divergent functions in macrophage responses to mycobacteria and LPS
Associate Advisor
Other advisors: Professor Antje Blumenthal
-
2015
Doctor Philosophy
Contributions of Wnt signalling to immune responses during acute bacterial infection
Associate Advisor
Other advisors: Professor Antje Blumenthal
-
2011
Doctor Philosophy
The effects of the balance of Type I and Type II NKT cells on CD8 T cells and Tumour Therapy
Associate Advisor
Other advisors: Associate Professor Graham Leggatt
-
2008
Doctor Philosophy
Interactions among Control Beliefs, Illness Severity, Biological Factors and a Psychological Preparation for Heart Surgery: Predictors of Health Outcomes
Associate Advisor
Other advisors: Emeritus Professor Kenneth Pakenham
-
2007
Doctor Philosophy
Treatment of Cervical Cancer using RNA-Interference Against Human Papillomavirus Oncogenes
Associate Advisor
-
2005
Doctor Philosophy
Regulation of squamous differentiation by the E2F family transcription factors
Associate Advisor
-
2003
Doctor Philosophy
DENDRITIC CELL IMMUNOTHERAPY BASED ON HUMAN PAPILLOMAVIRUS
Associate Advisor
Other advisors: Professor Ranjeny Thomas
-
2003
Doctor Philosophy
IDENTIFICATION AND CLONING OF GENES ASSOCIATED WITH SQUAMOUS CELL CARCINOMA IN HUMAN SKIN TUMOURS
Associate Advisor
-
2003
Doctor Philosophy
THE ROLE OF AP2 IN SQUAMOUS DIFFERENTIATION
Associate Advisor
-
Doctor Philosophy
Peripheral Mechanisms of CD8+ T Cell Tolerance in H-2b K14E7 Transgenic Mice
Associate Advisor
Other advisors: Associate Professor Graham Leggatt
Media
Enquiries
Contact Professor Ian Frazer directly for media enquiries about:
- Allergy
- Autoimmune disease
- Cancer - immunity
- Cancer - vaccines to prevent
- Cervical cancer vaccine
- Education - medical
- Genital wart virus disease
- Host-virus interactions
- Immunity
- Immunodeficiency
- Immunology
- Medical education
- Papillomavirus vaccines
- Pathology
- Transplantation immunology
- Tumour immunology
- Tumour vaccines
- Vaccines
- Viral infection
- Viral vaccines
- Viruses
- Warts - genital
Need help?
For help with finding experts, story ideas and media enquiries, contact our Media team: