
Overview
Background
Professor Ian Frazer is a clinician scientist, trained as a clinical immunologist in Scotland. As a professor at the University of Queensland, he leads a research group working at TRI in Brisbane, Australia on the immunobiology of epithelial cancers. He is recognised as co-inventor of the technology enabling the HPV vaccines, currently used worldwide to help prevent cervical cancer. He heads a biotechnology company, Jingang Medicine (Aus) Pty Ltd, working on new vaccine technologies, and is a board member of several companies and not for profit organisations. He was the inaugural president of the Australian Academy of Health and Medical Sciences, and a member of the Australian National Science and Technology Council. He chairs the Australian Medical Research Advisory Board of the Medical Research Future Fund.
He was recognised as Australian of the Year in 2006. He was recipient of the Prime Ministers Prize for Science, and of the Balzan Prize, in 2008, and was elected Fellow of the Royal Society of London in 2012. He was appointed Companion of the Order of Australia in the Queen’s Birthday Honours list in 2013.
Availability
- Professor Ian Frazer is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), University of Edinburgh
- Bachelor of Medicine Surgery, University of Edinburgh
- Doctoral Diploma of Medicine, University of Melbourne
- Royal College of Pathologists of Australasia, Royal College of Pathologists of Australasia
- Royal College of Physicians of Edinburgh, Royal College of Physicians of Edinburgh
Works
Search Professor Ian Frazer’s works on UQ eSpace
2004
Journal Article
Is vaccine therapy the future in cancer prevention?
Frazer, I. H. (2004). Is vaccine therapy the future in cancer prevention?. Expert Opinion on Pharmacotherapy, 5 (12), 2427-2434. doi: 10.1517/14656566.5.12.2427
2004
Conference Publication
Human papillomavirus
Frazer, IH (2004). Human papillomavirus. Conference on Vaccines, Prevention and Public Health, Washington Dc, Nov 25-27, 2002. WASHINGTON: PAN AMERICAN HEALTH ORGANIZATION.
2004
Journal Article
Cervical Cancer Control, Priorities and New Directions
Monsonego, J, Bosch, FX, Coursaget, P, Cox, JT, Franco, E, Frazer, I, Sankaranarayanan, R, Schiller, J, Singer, A, Wright, T, Kinney, W, Meijer, C and Linder, J (2004). Cervical Cancer Control, Priorities and New Directions. International Journal of Cancer, 108 (3), 329-333. doi: 10.1002/ijc.11530
2004
Journal Article
A major quantitative trait locus for CD4-CD8 ratio is located on chromosome 11
Evans, D. M., Zhu, G., Duffy, D. L., Frazer, I. H., Montgomery, G. W. and Martin, N. G. (2004). A major quantitative trait locus for CD4-CD8 ratio is located on chromosome 11. Genes and Immunity, 5 (7), 548-552. doi: 10.1038/sj.gene.6364126
2004
Journal Article
Mutations in TAP genes are common in cervical cancinomas
Fowler, NL and Frazer, IH (2004). Mutations in TAP genes are common in cervical cancinomas. Gynecologic Oncology, 92 (3), 914-921. doi: 10.1016/j.ygyno.2003.11.037
2004
Book Chapter
Vaccines Against Human Papillomavirus Infection
Boslego, J., Liu, X. and Frazer, I. H. (2004). Vaccines Against Human Papillomavirus Infection. New Generation Vaccines. (pp. 977-986) edited by Myron M. Levine, James B. Kaper, Rino Rappuoli, Margaret A. Liu and Michael F. Good. New York: Marcel Dekker, Inc..
2003
Journal Article
Effects of additional sequences directly downstream from the AUG on the expression of GFP gene
Zhao, Kong-Nan, Tomlinson, Liz, Liu, Wen Jun, Gu, Wenyi and Frazer, Ian H. (2003). Effects of additional sequences directly downstream from the AUG on the expression of GFP gene. BBA - Biochimeca et Biophysica Acta: international journal of biochemistry and biophysics, 1630 (2-3), 84-95. doi: 10.1016/j.bbaexp.2003.09.010
2003
Journal Article
IL-10 Mediates Suppression of the CD8 T Cell IFN-γ Response to a Novel Viral Epitope in a Primed Host
Liu, Xiao Song, Xu, Yan, Hardy, Lani, Khammanivong, Vithagna, Zhao, Weiming M., Fernando, Germain J. P., Leggatt, Graham R. and Frazer, Ian H. (2003). IL-10 Mediates Suppression of the CD8 T Cell IFN-γ Response to a Novel Viral Epitope in a Primed Host. Journal of Immunology, 171 (9), 4765-4772. doi: 10.4049/jimmunol.171.9.4765
2003
Journal Article
HPV 6b L1 virus-like particles elicit humoral immunity in mice
Liu, Yuehua, Liu, Wenjun, Liu, Xiaosong and Frazer, Ian H. (2003). HPV 6b L1 virus-like particles elicit humoral immunity in mice. Chinese Medical Sciences Journal, 18 (3), 185-188.
2003
Journal Article
Expression of the HPV16E7 oncoprotein by thymic epithelium is accompanied by disrupted T cell maturation and a failure of the thymus to involute with age
Malcolm, K. M., Gill, J., Leggatt, G. R., Boyd, R., Lambert, P. and Frazer, I. H. (2003). Expression of the HPV16E7 oncoprotein by thymic epithelium is accompanied by disrupted T cell maturation and a failure of the thymus to involute with age. Clinical and Developmental Immunology, 10 (2-4), 91-103. doi: 10.1080/10446670310001626562
2003
Journal Article
Inhibition of early tumor growth requires Jα18-positive (natural killer T) cells
Stewart, Trina J., Smyth, Mark J., Fernando, Germain J. P., Frazer, Ian H. and Leggatt, Graham R. (2003). Inhibition of early tumor growth requires Jα18-positive (natural killer T) cells. Cancer Research, 63 (12), 3058-3060.
2003
Journal Article
Chapter 16: Prophylactic Human Papillomavirus Vaccines
Lowy, Douglas R. and Frazer, Ian H. (2003). Chapter 16: Prophylactic Human Papillomavirus Vaccines. Journal of the National Cancer Institute Monographs, 31 (31), 111-116.
2003
Conference Publication
Immunotherapy for HPV associated pre-cancer
Frazer, Ian H., Leggatt, G. J., Matsumoto, K., De Kluyver, R., Quinn, M., Nicklin, J., Tan, J., Perrin, L., Ng, P., O'Connor, V., White, O., Wendt, N., Martin, J., Mitchelll, S.V., McKenzie, A., Crowley, J., Edwards, S. and Maher, D. (2003). Immunotherapy for HPV associated pre-cancer. Cancer Vaccine Collaborative 2002, Multiple locations, September 30 - October 1 2002. The Academy of Cancer Immunology.
2003
Journal Article
Paucity of functional CTL epitopes in the E7 oncoprotein of cervical cancer associated human papillomavirus type 16
Khammanivong, Vithagna, Liu, Xiao Song, Liu, Wen Jun, Rodda, Stuart J., Leggatt, Graham R., Tindle, Robert W., Frazer, Ian H. and Fernando, Germain J. P. (2003). Paucity of functional CTL epitopes in the E7 oncoprotein of cervical cancer associated human papillomavirus type 16. Immunology and Cell Biology, 81 (1), 1-7. doi: 10.1046/j.1440-1711.2003.01130.x
2003
Journal Article
Codon usage bias and A+T content variation in human papillomavirus genomes
Zhao, K. N., Liu, W. J. and Frazer, I. H. (2003). Codon usage bias and A+T content variation in human papillomavirus genomes. Virus Research, 98 (2), 95-104. doi: 10.1016/j.viruses.2003.08.019
2002
Journal Article
Saccharomyces cerevisiae is permissive for replication of bovine papillomavirus type 1
Zhao, Kong-Nan and Frazer, Ian H. (2002). Saccharomyces cerevisiae is permissive for replication of bovine papillomavirus type 1. Journal of Virology, 76 (23), 12265-12273. doi: 10.1128/JVI.76.23.12265-12273.2002
2002
Journal Article
Antigen-specific CD4+ T-Cell Help Is Required to Activate a Memory CD8+ T Cell to a Fully Functional Tumor Killer Cell
Gao, Feng Guang, Khammanivong, Vithagna, Liu, Wen Jun, Leggatt, Graham R., Frazer, Ian H. and Fernando, Germain J. P. (2002). Antigen-specific CD4+ T-Cell Help Is Required to Activate a Memory CD8+ T Cell to a Fully Functional Tumor Killer Cell. Cancer Research, 62 (22), 6438-6441.
2002
Journal Article
Vaccines for papillomavirus infection
Frazer, Ian H. (2002). Vaccines for papillomavirus infection. Virus Research, 89 (2), 271-274. doi: 10.1016/S0168-1702(02)00195-8
2002
Journal Article
Interferon-gamma enhances cytotoxic T lymphocyte recognition of endogenous peptide in keratinocytes without lowering the requirement for surface peptide
Leggatt, Graham R., Dunn, Linda A., De Kluyver, Rachel L., Stewart, Trina and Frazer, Ian H. (2002). Interferon-gamma enhances cytotoxic T lymphocyte recognition of endogenous peptide in keratinocytes without lowering the requirement for surface peptide. Immunology and Cell Biology, 80 (5), 415-424. doi: 10.1046/j.1440-1711.2002.01105.x
2002
Journal Article
Codon modified human papillomavirus type 16 E7 DNA vaccine enhances cytotoxic T-lymphocyte induction and anti-tumour activity
Liu, Wen Jun, Gao, Fengguang, Zhao, Kong Nan, Zhao, Weiming, Fernando, Germain J. G., Thomas, Ranjeny and Frazer, Ian H. (2002). Codon modified human papillomavirus type 16 E7 DNA vaccine enhances cytotoxic T-lymphocyte induction and anti-tumour activity. Virology, 301 (1), 43-52. doi: 10.1006/viro.2002.1584
Funding
Current funding
Past funding
Supervision
Availability
- Professor Ian Frazer is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
The role of IL34 in HPV-mediated epithelial cancers
Principal Advisor
Other advisors: Associate Professor Graham Leggatt, Professor David Hume, Dr Janin Chandra
-
Doctor Philosophy
The role of IL34 in HPV-mediated epithelial cancers
Principal Advisor
Other advisors: Associate Professor Graham Leggatt, Professor David Hume, Dr Janin Chandra
-
Doctor Philosophy
The role of IL34 in HPV-mediated epithelial cancers
Principal Advisor
Other advisors: Associate Professor Graham Leggatt, Professor David Hume, Dr Janin Chandra
-
Doctor Philosophy
The Role of Bacterially Induced Inflammation in Squamous Cell Carcinoma Development
Principal Advisor
Other advisors: Professor Phil Hugenholtz, Professor Mark Morrison, Dr Debottam Sinha, Dr Janin Chandra
-
Doctor Philosophy
Spatial Multi-Omics Analysis of HPV-Positive Head and Neck Cancer: Tumour Oncogenesis and Discovery of Targeted Therapies
Associate Advisor
Other advisors: Dr Quan Nguyen, Associate Professor James Wells, Dr Jazmina Gonzalez Cruz
-
Doctor Philosophy
Assessment of predictors of response to checkpoint blockades in cancer patients.
Associate Advisor
Other advisors: Dr Ahmed Mehdi, Dr Janin Chandra, Dr Bree Tillett
-
Doctor Philosophy
Spatial Multi-Omics Analysis of HPV-Positive Head and Neck Cancer: Tumour Oncogenesis and Discovery of Targeted Therapies
Associate Advisor
Other advisors: Dr Quan Nguyen, Associate Professor James Wells, Dr Jazmina Gonzalez Cruz
Completed supervision
-
2024
Doctor Philosophy
The Role of Bacterially Induced Inflammation in Squamous Cell Carcinoma Development
Principal Advisor
Other advisors: Professor Phil Hugenholtz, Professor Mark Morrison, Dr Debottam Sinha, Dr Janin Chandra
-
2021
Doctor Philosophy
The role of the skin microbiota in cutaneous squamous cell carcinoma
Principal Advisor
Other advisors: Professor Mark Morrison
-
2020
Doctor Philosophy
Modulation of Immune Responses by HPV-Induced Epithelial Hyperplasia
Principal Advisor
Other advisors: Associate Professor Graham Leggatt, Dr Janin Chandra
-
2018
Doctor Philosophy
Association of Local Immune Suppression in Skin with HPV-Induced Epithelial Hyperplasia
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2017
Master Philosophy
Aetiology of Oral Cavity Squamous Cell Carcinoma - An Exploration utilising Next Generation Sequencing
Principal Advisor
-
2015
Doctor Philosophy
Mechanisms of 2,4-Dinitrochlorobenzene-induced acute inflammation in Human Papillomavirus type 16 E7 oncoprotein expressing skin
Principal Advisor
-
2014
Doctor Philosophy
Mechanisms of immunoregulation in human papillomavirus-associated epithelial hyperplasia: of mice and (wo)men
Principal Advisor
Other advisors: Professor Antje Blumenthal
-
2013
Doctor Philosophy
LANGERHANS CELLS IN SKIN EXPRESSING HUMAN PAPILLOMAVIRUS TYPE 16 E7
Principal Advisor
-
2010
Doctor Philosophy
CD4+ T cells provide help to CD8+ T cells in immune recall responses in skin
Principal Advisor
-
2010
Doctor Philosophy
Augmenting CD8+ T cell-mediated cutaneous immunotherapy in a murine model system
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2010
Doctor Philosophy
Role of dendritic epidermal T cells in skin graft rejection
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2009
Doctor Philosophy
Human Papillomavirus 16 E7 Inhibits the ability of IFN-γ in Enhancement of MHC Class I Antigen Presentation and CTL Lysis by Affecting IRF-1 Expression in Keratinocytes
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
-
2008
Doctor Philosophy
Studies on mechanisms of skin graft rejection
Principal Advisor
Other advisors: Honorary Professor Geoffrey Hill
-
2003
Doctor Philosophy
IMMUNE RESPONSE TO PAPILLOMAVIRUS INFECTION
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2002
Doctor Philosophy
DETERMINING CTL CHARACTERISTICS WHICH CORRELATE WITH TUMOUR REGRESSION IN VIVO
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2023
Doctor Philosophy
Local Delivery Of Immunotherapeutic Antibodies To Skin Cancers
Associate Advisor
Other advisors: Dr Jazmina Gonzalez Cruz, Associate Professor Graham Leggatt
-
2022
Doctor Philosophy
Understanding CD4+ T cell responses to HPV16 E7 antigen in a mouse model of precancerous skin
Associate Advisor
Other advisors: Dr Kelvin Tuong, Dr Janin Chandra
-
2021
Doctor Philosophy
The role of CD8+ T cells in the regression of squamous cell carcinoma
Associate Advisor
Other advisors: Dr Jazmina Gonzalez Cruz, Associate Professor James Wells
-
2017
Doctor Philosophy
Uncovering novel regulators of CD8+ T-cell function in the skin
Associate Advisor
Other advisors: Associate Professor James Wells
-
2016
Doctor Philosophy
Evaluating CD8+ T-cell function in skin and squamous cell carcinoma following systemic suppression with rapamycin and tacrolimus.
Associate Advisor
Other advisors: Professor Fiona Simpson, Associate Professor James Wells
-
2015
Doctor Philosophy
Characterisation of RP105's divergent functions in macrophage responses to mycobacteria and LPS
Associate Advisor
Other advisors: Professor Antje Blumenthal
-
2015
Doctor Philosophy
Contributions of Wnt signalling to immune responses during acute bacterial infection
Associate Advisor
Other advisors: Professor Antje Blumenthal
-
2011
Doctor Philosophy
The effects of the balance of Type I and Type II NKT cells on CD8 T cells and Tumour Therapy
Associate Advisor
Other advisors: Associate Professor Graham Leggatt
-
2008
Doctor Philosophy
Interactions among Control Beliefs, Illness Severity, Biological Factors and a Psychological Preparation for Heart Surgery: Predictors of Health Outcomes
Associate Advisor
Other advisors: Emeritus Professor Kenneth Pakenham
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2007
Doctor Philosophy
Treatment of Cervical Cancer using RNA-Interference Against Human Papillomavirus Oncogenes
Associate Advisor
-
2005
Doctor Philosophy
Regulation of squamous differentiation by the E2F family transcription factors
Associate Advisor
-
2003
Doctor Philosophy
DENDRITIC CELL IMMUNOTHERAPY BASED ON HUMAN PAPILLOMAVIRUS
Associate Advisor
Other advisors: Professor Ranjeny Thomas
-
2003
Doctor Philosophy
THE ROLE OF AP2 IN SQUAMOUS DIFFERENTIATION
Associate Advisor
-
2003
Doctor Philosophy
IDENTIFICATION AND CLONING OF GENES ASSOCIATED WITH SQUAMOUS CELL CARCINOMA IN HUMAN SKIN TUMOURS
Associate Advisor
-
Doctor Philosophy
Peripheral Mechanisms of CD8+ T Cell Tolerance in H-2b K14E7 Transgenic Mice
Associate Advisor
Other advisors: Associate Professor Graham Leggatt
Media
Enquiries
Contact Professor Ian Frazer directly for media enquiries about:
- Allergy
- Autoimmune disease
- Cancer - immunity
- Cancer - vaccines to prevent
- Cervical cancer vaccine
- Education - medical
- Genital wart virus disease
- Host-virus interactions
- Immunity
- Immunodeficiency
- Immunology
- Medical education
- Papillomavirus vaccines
- Pathology
- Transplantation immunology
- Tumour immunology
- Tumour vaccines
- Vaccines
- Viral infection
- Viral vaccines
- Viruses
- Warts - genital
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